中国耳鼻咽喉头颈外科2024，Vol.31Issue(11)：722-726,5.DOI:10.16066/j.1672-7002.2024.11.009
细菌溶解产物治疗慢性鼻窦炎的疗效分析
Efficacy analysis of bacterial lysates in the treatment of chronic rhinosinusitis
摘要
Abstract
OBJECTIVE To observe the curative effect of bacterial lysates(BLs)combined with intranasal corticosteroids(INCS)in the treatment of chronic rhinosinusitis(CRS).METHODS Cases diagnosed as CRS with nasal polyps(CRSwNP)and CRS without nasal polyps(CRSsNP)were collected and divided into four groups:CRSwNP with BLs group,CRSwNP control group,CRSsNP with BLS group and CRSsNP control group.All patients received surgical treatment,the control group received postoperative INCS therapy,and the BLs group received postoperative INCS+BLs oral therapy.Visual analogue scale(VAS),sino-nasal outcome test-20(SNOT-20),Lund-Kennedy score,Lund-Mackay score,eosinophilic(Eos)cell,IL-4,IgG,IgA,IgM and total IgE levels were evaluated before,1 month and 3 months after surgery.RESULTS Significant differences in IgG,IgA,IL-4 and Eos levels between CRSwNP and CRSsNP with BLs groups(P<0.05).There were significant differences in VAS and SNOT-20 between CRSwNP group and CRSsNP with BLs group at 1 and 3 months after treatment(P<0.05).At 1 month and 3 months after treatment,there were statistically significant differences in Lund-Kennedy score and Lund-Mackey score between the CRSwNP group and the CRSsNP with BLs group(P<0.05).The effective rate of disease control in the four groups after treatment was statistically significant(P<0.05).There were no serious complications directly related to the treatment.CONCLUSION The application of BLs can improve postoperative rhinorrhea,persistent inflammatory and mucosal recovery in patients with CRS,increase IgG and IgA levels,reduce Eos and IL-4 levels,reduce adverse reactions,and improve the therapeutic effect of CRS with high safety.关键词
鼻窦炎/鼻息肉/慢性鼻窦炎伴鼻息肉/慢性鼻窦炎不伴鼻息肉/细菌溶解产物Key words
Sinusitis/Nasal Polyps/chronic rhinosinusitis with nasal polyps/chronic rhinosinusitis without nasal polyps/bacterial lysates引用本文复制引用
李欣,何健,李聪,张玥钰,刘雪峰,吕芸..细菌溶解产物治疗慢性鼻窦炎的疗效分析[J].中国耳鼻咽喉头颈外科,2024,31(11):722-726,5.基金项目
甘肃省人民医院科技计划项目(20JR10RA391) （20JR10RA391）
