海南医学院学报2024，Vol.30Issue(23)：1817-1826,10.DOI:10.13210/j.cnki.jhmu.20240417.002
伴中央颞区棘波儿童自限性癫痫的静息态自发脑活动改变:基于激活似然估计的Meta分析
Changes in resting spontaneous brain activity children with central temporal spikes in self limiting epilepsy:A meta-analysis based on activation likelihood estimation
摘要
Abstract
Objective:To investigate the functional changes of local brain regions in children with self-limited epilepsy with centrotemporal spikes(SeLECTS)through a meta-analysis of activation likelihood estimation.Methods:Chinese and foreign data-bases were systematically searched for literatures on changes in spontaneous brain activity in children with centrotemporal self-limiting epilepsy from the establishment of database to January 25,2024.A voxel-based meta-analysis was used to comprehen-sively analyze the studies on changes in local brain function between children and healthy controls.The correlation of Meta results with demographic variables and clinical information was calculated by meta-regression analysis.Results:Full effect meta-analysis found increased spontaneous brain activity in the right precentral gyrus.The locally consistent meta-analysis did not find an in-crease or decrease in spontaneous brain activity.Right postcentral gyrus,left insula and right anterior cingulate gyrus,while de-creased in the left middle temporal gyrus,left precuneus and left middle occipital gyrus.Meta-regression analysis showed that the spontaneous activity of the SeLECTS in the right anterior central gyrus was positively correlated with age.Conclusion:Spontane-ous brain activity in several brain regions of SeLECTS is abnormal in children with SeLECTS,and the functional changes in brain regions can help to better explain the pathogenesis of SeLECTS,and provide reference for further research on the imaging mecha-nism of SELECTS.关键词
伴中央颞区棘波儿童自限性癫痫/静息态功能磁共振/Meta分析/激活似然估计法/自发的神经活动Key words
Self-limited epilepsy with centrotemporal spikes/Resting state functional magnetic resonance imaging/Meta analysis/Activation likelihood estimation method/Spontaneous neural activity分类
医药卫生引用本文复制引用
栾超,刘婷,林慧霞,杨逸昊,栗菲,张芷菡,梁斌基,李其富..伴中央颞区棘波儿童自限性癫痫的静息态自发脑活动改变:基于激活似然估计的Meta分析[J].海南医学院学报,2024,30(23):1817-1826,10.基金项目
This study was supported by Key R&D Program of Hainan Province(ZDYF2022SHFZ109),Epilepsy Research Innovation Team of Hainan Medical College(2022),Excellent Talent Team of Hainan Province(QRCBT202121),and Hainan Clinical Medical Center Construction Project(2021) 海南省重点研发计划(ZDYF2022SHFZ109) （ZDYF2022SHFZ109）
海南医学院癫痫研究创新团队(2022) （2022）
海南省优秀人才团队(QRCBT202121) （QRCBT202121）
海南省临床医学中心建设项目(2021) （2021）
