海南医学院学报2024，Vol.30Issue(23)：1833-1840,8.DOI:10.13210/j.cnki.jhmu.20240823.003
线粒体质量控制在COPD中的作用及治疗进展
The mechanism and therapeutic progress of mitochondrial quality control(MQC)in COPD
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is one of the common diseases worldwide,with a complex patho-genesis that is still not fully understood,andcurrent treatment methods still have limitations.Mitochondrial quality control(MQC)mainly refers to the selective removal of damaged or aged mitochondria and the generation of new mitochondria,involving mito-chondrial biogenesis,mitochondrial dynamics,mitosis,etc.More and more evidence suggests that mitochondrial quality control imbalance plays an important role in COPD.This article reviews the mechanism of MQC in COPD and summarizes the progress of mitochondrial related therapies for COPD,in order to provide reference and inspiration for new strategies for COPD treatment.关键词
慢性阻塞性肺疾病/线粒体动力学/线粒体质量控制Key words
Chronic obstructive pulmonary disease/Mitochondrial dynamics/Mitochondrial quality control分类
医药卫生引用本文复制引用
何光亮,王丹心,刘磊,叶敏..线粒体质量控制在COPD中的作用及治疗进展[J].海南医学院学报,2024,30(23):1833-1840,8.基金项目
Natural Science Foundation of Hainan Province(822RC833) （822RC833）
Hainan Province Higher Education Science Research Project(Hnky2021ZD-15) 海南省自然科学基金资助项目(822RC833) （Hnky2021ZD-15）
海南省高等学校科学研究项目(Hnky2021ZD-15) （Hnky2021ZD-15）
