河南中医2024，Vol.44Issue(12)：1827-1830,4.DOI:10.16367/j.issn.1003-5028.2024.12.0329
抽动障碍从脾胃论治
Treating Tic Disorders from the Perspective of the Spleen and Stomach
摘要
Abstract
The pathogenesis of tic disorders is primarily associated with neurotransmitter dysregulation in the cortico-basal ganglia-thalamo-cortical circuit.Gut microbiota can communicate bidirectionally with the central nervous system through immune,endocrine,and neural pathways,exerting regulatory effects.According to TCM,the main pathogenesis of tic disorders is considered to be weakness of the spleen and stomach leading to wind,with weakness of the spleen and stomach as the root and wind manifestations as the symptoms.The intestinal microbiome plays a role in assisting digestion in the gastrointestinal tract and participating in the metabolism of carbohy-drates,lipids,and proteins,producing numerous nutrients beneficial to the body.In physiological state,the clear yang rises to the upper orifices,while the turbid yin descends to the lower orifices.Yang governs the function of qi,while yin forms the body.The most important principle is"inhaling the clear and exhaling the turbid."The"clear"substances such as sugar,fat,and protein produced by the gut microbiota metabolism serve as nourishment for the body,while the"turbid"substances such as immune and inflammatory factors,in-dole-3-phosphate sulfate,and imbalanced neurotransmitters are neurotoxic metabolites that disrupt the brain-stem-thalamus-cortex cir-cuit.The healthy functioning of the spleen's"raising the clear"and stomach's"descending the turbid"functions is closely related to the stability of the gut microbiota and its normal function.Therefore,treating tic disorders from the perspective of the spleen and stomach can regulate the gut microbiota and improve the dysfunction of the cortex-basal ganglia-thalamus-cortex circuit,thereby exerting its ther-apeutic effects.关键词
抽动障碍/肠道菌群/从脾胃论治/脑-肠轴理论Key words
tic disorders/gut microbiome/treatment based on the spleen and stomach/brain-gut axis theory分类
医药卫生引用本文复制引用
张永莹,许洪义,徐曼曼..抽动障碍从脾胃论治[J].河南中医,2024,44(12):1827-1830,4.基金项目
山东省中医药科技面上项目(2020M200) （2020M200）
