河南中医2024，Vol.44Issue(12)：1932-1938,7.DOI:10.16367/j.issn.1003-5028.2024.12.0349
针刺调节阿尔茨海默病经典信号通路研究进展
Research Progress in the Mechanisms of Acupuncture Regulation of Classic Signaling Pathways in Alzheimer's Disease
摘要
Abstract
Acupuncture has shown potential in alleviating Alzheimer's disease(AD)through various mechanisms,with classic signaling pathways such as PI3K/Akt,p38MAPK,and TLR4/NF-κB playing significant roles in regulating cell apoptosis,neuronal injury,inflam-mation,and immune activation,etc.Most current studies focus on single signaling pathways,though the relationship between these path-ways and AD is highly complex and may vary across pathological stages and cell types.Additionally,while animal studies suggest that acupuncture effectively mitigates AD-related pathology,the limited acupuncture points used in these studies may not fully align with clinical syndrome differentiation.This can result in notable discrepancies between experimental and clinical outcomes due to multiple in-fluencing factors.In the future,research should benefit from an integrative approach examining multiple pathways to uncover new thera-peutic targets for AD,investigate different pathological stages,and conduct large-scale,standardized clinical studies to provide more ro-bust and effective evidence for clinical practice.关键词
阿尔茨海默病/针刺/信号通路/老年性痴呆Key words
Alzheimer's disease(AD)/acupuncture/signaling pathways/senile dementia分类
医药卫生引用本文复制引用
江东林,杜艳军..针刺调节阿尔茨海默病经典信号通路研究进展[J].河南中医,2024,44(12):1932-1938,7.基金项目
国家自然科学基金项目(82374564,82074566) （82374564,82074566）
国家中医药管理局"全国名中医传承工作室"建设项目{国中医药人教发[2022]5 号} （）
湖北省自然科学联合基金重点项目(2023AFD112) （2023AFD112）
