壳聚糖基静电纺丝纳米纤维的制备及在组织工程中的应用OA北大核心CSTPCD

Electrospinning is a simple and efficient technology used to prepare continuous nano or microfibers.Chitosan is the only natural alkaline cationic polysaccharide.Chitosan-based nanofibers prepared through electro-spinning have the advantages of large specific surface area,high porosity,strong drug delivery ability,good bio-compatibility,good biodegradability,hemostasis,antibacterial ability,and healing promotion ability.Hence,they have broad application prospects in the field of tissue engineering.The preparation of chitosan-based electrospin-ning nanofibers and research advances of such nanofibers in bone,skin,blood vessels,and nerve tissue engineering have been reviewed.Finally,we present the future development direction of chitosan-based electrospinning nano-fibers in tissue engineering and expect to provide a theoretical reference for future research.