喉罩麻醉与气管插管麻醉在低龄先天性心脏病患儿介入封堵术中的应用比较OACSTPCD
Comparison of laryngeal mask airway anesthesia and endotracheal intubation anesthesia in interventional occlusion for young-age patients with congenital heart disease
目的 比较喉罩麻醉与气管插管麻醉在低龄先天性心脏病(简称先心病)患儿介入封堵术中的应用效果.方法 选取102例接受介入封堵术治疗的低龄先心病患儿作为研究对象,采用随机数字表法分为对照组和观察组,每组51例.对照组实施气管插管麻醉,观察组实施喉罩下七氟烷全凭吸入麻醉.比较2组苏醒时间、拔管时间、喉痉挛发生率和肺部感染发生率,并比较2组不同时点血流动力学指标[心率(HR)、平均动脉压(MAP)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]、心肌损伤指标[肌酸激酶同工酶(CK-MB)、心脏型脂肪酸结合蛋白(H-FABP)]水平.结果 观察组苏醒时间、拔管时间短于对照组,肺部感染率、喉痉挛发生率低于对照组,差异有统计学意义(P＜0.05).麻醉前(T0),2组患儿HR、MAP、MDA、SOD、CK-MB、H-FABP水平比较,差异无统计学意义(P＞0.05);置入喉罩或插管时(T1)、动静脉穿刺时(T2)、置入封堵器即刻(T3),观察组患儿HR、MAP、CK-MB、H-FABP水平均低于对照组,差异有统计学意义(P＜0.05);T1、T2、T3时点,2组患儿MDA水平均高于T0时点,SOD水平均低于T0时点,但观察组MDA水平低于对照组,SOD水平高于对照组,差异有统计学意义(P＜0.05).结论 相较于气管插管麻醉,喉罩下七氟烷全凭吸入麻醉在低龄先心病患儿介入封堵术治疗中的应用效果更佳,能够有效维持术中血流动力学稳定,缩短苏醒时间和拔管时间,且安全性较高.
Objective To compare the application effects of laryngeal mask airway anesthesia and endotracheal intubation anesthesia in interventional occlusion for young-age patients with congeni-tal heart disease.Methods A total of 102 young-age patients with congenital heart disease undergo-ing interventional occlusion were enrolled and randomly divided into control group and observation group using a random number table method,with 51 patients in each group.The control group re-ceived endotracheal intubation anesthesia,while the observation group received sevoflurane anesthesia via laryngeal mask airway.The awakening time,extubation time,incidence of laryngeal spasm,and incidence of lung infection were compared between the two groups.Additionally,hemodynamic pa-rameters[heart rate(HR),mean arterial pressure(MAP)],oxidative stress indicators[malondial-dehyde(MDA),superoxide dismutase(SOD)],and myocardial injury indicators[creatine kinase-MB(CK-MB),heart-type fatty acid-binding protein(H-FABP)]levels at different time points were compared.Results The observation group had shorter awakening time and extubation time,and low-er incidence of lung infection and laryngeal spasm compared with the control group(P＜0.05).Before anesthesia(T0),there were no statistically significant differences in HR,MAP,MDA,SOD,CK-MB,and H-FABP levels between the two groups(P＞0.05).During laryngeal mask insertion or intuba-tion(T1),during arteriovenous puncture(T2),and immediately after occluder placement(T3),the observation group had lower HR,MAP,CK-MB,and H-FABP levels compared with the control group(P＜0.05).At T1,T2,and T3,the MDA levels in both groups were higher than that at T0,and the SOD levels were lower than that at T0;however,the observation group had lower MDA lev-els and higher SOD levels compared with the control group(P＜0.05).Conclusion Compared with endotracheal intubation anesthesia,sevoflurane anesthesia via laryngeal mask airway has a bet-ter application effect in interventional occlusion for young-age patients with congenital heart disease,thereby effectively maintaining intraoperative hemodynamic stability,shortening awakening time and extubation time,and exhibiting higher safety.
戴丹;刘婷婷;高静;胡瑶琴
浙江大学医学院附属儿童医院麻醉科,浙江 杭州,311200
临床医学
喉罩气管插管先天性心脏病低龄患儿介入封堵术血流动力学肺部感染喉痉挛
laryngeal maskendotracheal intubationcongenital heart diseaseyoung-age childreninterventional occlusionhemodynamicslung infectionlaryngeal spasm
《实用临床医药杂志》 2024 (022)
16-20 / 5
国家自然科学基金项目(81901937)
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