实用临床医药杂志2024，Vol.28Issue(22)：52-54,61,4.DOI:10.7619/jcmp.20240863
具有间变形态的滤泡性淋巴瘤3例临床病理分析
Clinicopathological analysis of three follicular lymphoma cases with anaplastic morphology
摘要
Abstract
Objective To investigate the clinicopathological features,immunophenotype,molec-ular characteristics,differential diagnosis,and prognosis of follicular lymphoma with anaplastic mor-phology.Methods Immunohistochemical EnVision two-step method was used to detect the expres-sions of CD20,PAX5,CD10,BCL6,MUM-1,BCL2,CD30,Ki-67,and other markers in three ca-ses of follicular lymphoma with anaplastic morphology.In situ fluorescence hybridization was used to detect BCL2,BCL6,and MYC gene translocations.The clinicopathological features,diagnosis,differ-ential diagnosis,and prognosis of follicular lymphoma with anaplastic morphology were analyzed.Re-sults The follicular lymphoma with anaplastic morphology in this study exhibited high-grade features and occurred in middle-aged and elderly patients.Immunohistochemically,the tumors expressed panB markers,were negative for CD10,positive for BCL6,mostly positive for MUM1,and positive for c-myc expression.However,no BCL6 or MYC gene translocations were detected.Conclusion Follicu-lar lymphoma with anaplastic morphology is uncommon and mostly presents as high-grade follicular lymphoma.It is important to correctly recognize its various morphological variants.关键词
滤泡性淋巴瘤/间变/变异型/临床病理特征/鉴别诊断Key words
follicular lymphoma/anaplasia/variant types/clinicopathological features/differ-ential diagnosis分类
医药卫生引用本文复制引用
吴梅,王铮,刘慧,于鸿..具有间变形态的滤泡性淋巴瘤3例临床病理分析[J].实用临床医药杂志,2024,28(22):52-54,61,4.基金项目
江苏省泰州市社会发展项目(TS202309) （TS202309）
