实用临床医药杂志2024，Vol.28Issue(22)：78-81,87,5.DOI:10.7619/jcmp.20242829
急性心肌梗死后血清脂联素水平变化及其与心力衰竭和主要不良心血管事件的关系
Changes in serum adiponectin levels after acute myocardial infarction and its relationships with heart failure and major adverse cardiac events
摘要
Abstract
Objective To analyze the dynamic changes in serum adiponectin(APN)levels after acute myocardial infarction(AMI)and its relationship with heart failure(HF)and major adverse cardiovascular events(MACE).Methods A total of 124 AMI patients who underwent percutaneous coronary intervention(PCI)in our hospital from January 2021 to December 2023 were enrolled as AMI group.Additionally,30 patients with non-AMI coronary artery disease and 30 healthy individu-als were included in non-AMI coronary artery disease group and healthy group,respectively.General information such as age,gender,smoking,alcohol consumption,hypertension,diabetes,and blood lipids were recorded for all subjects.Serum APN levels were measured using the enzyme-linked im-munosorbent assay(ELISA)method;plasma brain natriuretic peptide(BNP)levels were determined by immunofluorescence;and left ventricular ejection fraction(LVEF)was assessed using echocardio-graphy.Changes in serum APN levels and its relationship with BNP,LVEF,and MACE were recor-ded during a one-year follow-up period.Results AMI patients had lower serum APN levels than those in the non-AMI coronary artery disease group and the healthy group,while levels of total choles-terol(TC),low-density lipoprotein cholesterol(LDL-C);Lipoprotein-associated phospholipase A2(Lp-PLA2),and the proportions of smokers and diabetics were higher(P＜0.05).A one-year follow-up of AMI patients revealed an upward trend in serum APN and BNP levels and a downward trend in LVEF levels at one week,one month,three months,six months,and one year postoperatively(P＜0.05).APN and BNP levels peaked one month after PCI,while LVEF reached its lowest level at the same time point.However,there were no statistically significant changes in these indicators in the subsequent 11 months(P＞0.05).The incidence of MACE in AMI patients at one,three,six,and twelve months postoperatively was 2.8％,3.2％,4.6％,and 8.8％,respectively.Both preoper-ative and one-month postoperative serum APN levels had high predictive value for the occurrence of HF and MACE within one year in AMI patients,and the area under the curve for predicting HF and MACE one month postoperatively was larger than that preoperatively(P＜0.05).Conclusion Ser-um APN levels in AMI patients show an upward trend after PCI,peaking one month postoperatively.At this time point,serum APN levels have the highest predictive value for the occurrence of HF and MACE.关键词
急性心肌梗死/脂联素/心力衰竭/主要不良心血管事件Key words
acute myocardial infarction/adiponectin/heart failure/major adverse cardiac e-vents分类
医药卫生引用本文复制引用
茆文群,张翥,范修才,祁建成,陈旭..急性心肌梗死后血清脂联素水平变化及其与心力衰竭和主要不良心血管事件的关系[J].实用临床医药杂志,2024,28(22):78-81,87,5.基金项目
江苏省盐城市科技计划项目(YK2021082) （YK2021082）
