军事医学2024，Vol.48Issue(11)：838-842,5.DOI:10.7644/j.issn.1674-9960.2024.11.006
空军飞行人员甲状腺乳头状癌BRAF V600E突变及临床病理分析
BRAF V600E mutation and clinicopathologic analysis of papillary thyroid carcinoma in Air Force flight peronnel
摘要
Abstract
Objective To investigate the characteristics and clinicopathology of v-raf murine sarcoma viral oncogene homolog Bl(BRAF)V600E mutations in papillary thyroid carcinoma(PTC)in Air Force flight personnel.Methods Data of cases and test results of BRAF V600E mutation were collected from Air Force aviators pathologically diagnosed with PTC.A univariate analysis of the relationship between BRAF V600E mutations and clinicopathologic features was performed.Results The overall rate of BRAF V600E mutations among 55 PTC flight crew members was 70.91％.The univariate analysis showed that the number of lymph node metastases in the BRAF V600E mutated group was larger than in the BRAF V600E unmutated group,and the proportion of BRAF V600E mutations in flight crews at intermediate risk of recurrence was higher than that in those at low risk of recurrence(P＜0.05).The presence or absence of BRAF V600E mutations did not affect the results of medical evaluation of PTC in flight personnel.Conclusion The rate of PTC BRAF V600E mutations in Air Force flight crews is similar to that of the general Chinese population.BRAF V600E mutations are associated with an increased number of lymph node metastases and risk of recurrence,and follow-up is recommended for flight personnel with PTC,especially those with BRAF V600E mutations.关键词
鼠类肉瘤病毒癌基因同源物B1 V600E/基因突变/甲状腺乳头状癌/空军飞行人员Key words
v-raf murine sarcoma viral oncogene homolog B1 V600E/genetic mutation/papillary thyroid cancer/Air Force flight personnel分类
医药卫生引用本文复制引用
周广鑫,侯金正,张妲,肖黎,朱慧娟,杜俊杰,崔丽,顾国利,管浩军,陶玉坤,朱慧静..空军飞行人员甲状腺乳头状癌BRAF V600E突变及临床病理分析[J].军事医学,2024,48(11):838-842,5.基金项目
空军后勤部军队重点项目(BKJ20J004) （BKJ20J004）
