解放军医学院学报2024，Vol.45Issue(9)：1000-1005,6.DOI:10.12435/j.issn.2095-5227.2024.067
航天环境调节肠道菌群及其代谢产物的研究进展
Research advances in regulation of intestinal flora and its metabolites by space environment
摘要
Abstract
Intestinal flora is an important part of the human intestinal microenvironment,which can interact with the immune,metabolic and nervous systems,and is the basic determinant of multiple physiological and pathological processes of the human body.Gut microbiota metabolites are important links for gut microbiota to regulate body homeostasis,including metabolites produced by gut bacteria decomposing dietary components,metabolites produced by the host and modified by gut bacteria,and metabolites synthesized de novo by gut bacteria.Microgravity,radiation and dietary changes during space flight have a significant impact on the composition and metabolic pathway of intestinal flora,promote the change of intestinal flora,the imbalance of the proportion of Firmicum/Bacteroides,the decrease of beneficial metabolites and the increase of harmful metabolites,and induce the dysfunction of immune,cardiovascular,muscle and bone systems,thus affecting the physiological health of the body.Recent research advances in regulation of intestinal flora and its metabolites by space environment are reviewed in this paper.关键词
航天环境/肠道菌群/短链脂肪酸/微重力/辐射Key words
space environment/intestinal flora/short chain fatty acid/weightlessness/radiation分类
医药卫生引用本文复制引用
王艺璇,柴欣,王宏丽,洪金鹏,王彪猛,陈嘉屿..航天环境调节肠道菌群及其代谢产物的研究进展[J].解放军医学院学报,2024,45(9):1000-1005,6.基金项目
国家自然科学基金青年基金项目(82302112) （82302112）
甘肃省青年科技基金项目(23JRRA320) （23JRRA320）
