兰州大学学报（医学版）2024，Vol.50Issue(11)：39-44,6.DOI:10.13885/j.issn.1000-2812.2024.11.006
远隔缺血适应改善急性脑梗死患者神经功能的临床研究
Clinical research into remote ischemic conditioning on improving neurological function in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the effects of remote ischemic conditioning(RIC)treatment on neurologi-cal function,mobility,clinical efficacy and safety in patients with acute cerebral infarction.Methods A total of 178 patients,who were diagnosed with acute cerebral infarction in the internal carotid artery system(NI-HSS score of 6-16)via magnetic resonance imaging at the neurology department of The People's Hospital of Suzhou New District between January 2022 and December 2023 were selected as the study subjects.They were assigned to an experimental group(n=92)and a control one(n=86).The former received additional RIC therapy accompanied by standard treatment,and the latter only standard treatment.After six months of treat-ment,the efficacy and treatment-related adverse events of the two groups were carefully evaluated and com-pared.Statistical analysis was conducted on the patient's neurological function,mobility,clinical efficacy score,and treatment safety before and after the treatment.Results After six months of follow-up,70.65%of patients in the treatment group had an mRS score of 0-1,significantly higher than the control group(54.65%,P<0.05).The Fugl-Meyer score of upper limbs in the treatment group was(48.26±5.20),which was signifi-cantly improved compared with(37.50±3.10)in the control(P<0.05).At the same time,the lower limbs Fugl-Meyer score of(33.42±3.50)in the treatment group was also significantly higher than(28.60±2.50)in the control(P<0.05).The NIHSS scores of both were lower than that at admission,and the score in the experimental group decreased to(5.96±1.99),which was lower than the control's(9.04±2.94)(P<0.05).Conclusions The addition of RIC therapy on the basis of standard treatment has significant benefits for the rehabilitation of patients with acute cerebral infarction.It can effectively enhance the treatment effect,im-prove the patient's symptoms,and reduce disability rates.关键词
急性脑梗死/远隔缺血适应/美国国立卫生研究院卒中量表/改良Rankin评分/有效性/安全性Key words
acute cerebral infarction/remote ischemic conditioning/national institutes of health stroke scale/modified rankin scale/validity/security分类
医药卫生引用本文复制引用
马临庆,张立梅,任丽艳,孙璐,崔俊一,周丽华..远隔缺血适应改善急性脑梗死患者神经功能的临床研究[J].兰州大学学报（医学版）,2024,50(11):39-44,6.基金项目
苏州市第十八批科技发展计划(民生科技)资助项目(SS2019046) （民生科技）
苏州市临床重点病种诊疗技术专项资助项目(LCZX202028) （LCZX202028）
