兰州大学学报（医学版）2024，Vol.50Issue(11)：69-78,94,11.DOI:10.13885/j.issn.1000-2812.2024.11.010
基因多态性在全身麻醉药物中的研究进展
Progress in research of genetic polymorphism in general anesthesia drugs
摘要
Abstract
The metabolic process of drugs in the body involves various proteins,such as metabolic enzymes,transport proteins and receptors,and the synthesis of these proteins is controlled by genes.Pharmacogenomics is a discipline studying how changes in gene function affect pharmacokinetics and pharmacodynamics.Gene polymorphism affects the metabolism rate and pharmacological effects by affecting the polymorphism of genes's encoding drug metabolism enzymes and receptor proteins.Anesthetic drugs,as ones regulating the function of the nervous system,show significant differences in individuals,which may be due to a combi-nation of individual clinical characteristics and genetic factors.This review provided a summary of recent research on genetic polymorphism in general anesthetic drugs,aiming at contributing to the implementation of precision anesthesia in clinical practice,enhancing drug efficacy and reducing adverse drug reactions.关键词
麻醉药/基因多态性/静脉麻醉药/吸入麻醉药/阿片类药物/肌松药Key words
anesthetics/genetic polymorphism/intravenous anesthetics/inhalation anesthetics/opioid drugs/muscle relaxants分类
医药卫生引用本文复制引用
于敏,李亚龙,胡晓霞,马玉龙,刘欣跃..基因多态性在全身麻醉药物中的研究进展[J].兰州大学学报（医学版）,2024,50(11):69-78,94,11.基金项目
甘肃省自然科学基金资助项目(23JRRA1619) （23JRRA1619）
