食管疾病2024，Vol.6Issue(4)：260-266,7.DOI:10.15926/j.cnki.issn2096-7381.2024.04.004
MRI定量参数作为食管癌放化疗早期治疗反应预测指标的Meta分析
Meta Analysis of MRI Quantitative Parameters as Predictive Indicators for Early Treatment Response to Radiotherapy and Chemotherapy in Esophageal Cancer
摘要
Abstract
Objective To evaluate the role of MRI quantitative parameters as predictors of response to chemoradiotherapy in patients with EC.Methods Chinese and English databases were retrieved,and eligi-ble studies were included.Stata 15.0 was used for data analysis,and Meta-analysis was conducted with biva-riate mixed-effects model.The pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ra-tio,diagnostic odds ratio and 95%confidence interval(95%CI)of the effect size were calculated.The re-ceiver operating characteristic curve was drawn.The diagnostic efficiency by evaluating the area under the curve(AUC)was calculated.Results 18 articles were included,with a cumulative sample size of 1100 patients,including 630 cases with treatment response was effective.The accuracy of △ADC(the change of ADC value before and during treatment)in identifying therapeutic response to radiotherapy and chemotherapy in EC patients was evaluated.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio and SROC were 0.79(95%CI:0.68～0.87),0.87(95%CI:0.72～0.95),6.1(95%CI:2.8～13.5),0.24(95%CI:0.16～0.36),25(95%CI:11～60),and 0.89(95%CI:0.86～0.91),re-spectively.Conclusion △ADC can serve as a predictive indicator for therapeutic response and as a tool to guide clinical decision-making.关键词
食管癌/ADC/容量转移常数/Meta分析Key words
esophageal cancer/ADC/Ktrans/Me-ta分类
医药卫生引用本文复制引用
袁芳,李莹莹,倪莉,李小潘,李新瑜..MRI定量参数作为食管癌放化疗早期治疗反应预测指标的Meta分析[J].食管疾病,2024,6(4):260-266,7.基金项目
河南科技大学第一附属医院科技攻关重点项目(ZLKFJJ20230409) （ZLKFJJ20230409）
