食管疾病2024，Vol.6Issue(4)：288-291,300,5.DOI:10.15926/j.cnki.issn2096-7381.2024.04.009
降钙素基因相关肽及血红素氧合酶-1对反流性食管炎病情评估及预后的价值分析
Severity Evaluation and Prognosis Value of Calcitonin Gene-related Peptide and Heme Oxygenase-1 in Reflux Esophagitis
李凤敏1
作者信息
- 1. 开封市人民医院消化内科,河南 开封,475000
- 折叠
摘要
Abstract
Objective To analyze the prognostic value of serum CGRP and heme oxygenase-1(HO-1)in reflux esophagitis(RE).Methods 90 RE patients admitted to our hospital from June 2022 to May 2023 were selected as the observation group,and 45 healthy people who participated in physical examination during the same period were selected as the control group.The correlations between serum CGRP,HO-1 lev-els,GerdQ score,as well as their combined prognostic value were analyzed.Results The levels of serum CGRP and HO-1 in the observation group patients increased compared to the control group(P＜0.001).The levels of serum CGRP,HO-1,and GerdQ score in the moderate group were higher than those in the mild group,while levels of serum CGRP,HO-1,and GerdQ score in the severe group showed an increase com-pared to the moderate group(P＜0.05).The Pearson correlation analysis results showed that the serum CGRP level and HO-1 level of RE patients were positively correlated with GerdQ score(P＜0.01).The area under the curve(AUC)of serum CGRP and HO-1 predicting poor prognosis in RE patients was 0.841 and 0.877,respectively,and the combination of the two increased the AUC to 0.937.Conclusion The combination of serum CGRP and HO-1 has a high predictive value for the prognosis of RE patients.关键词
反流性食管炎/血清/CGRP/HO-1/预后Key words
reflux esophagitis/serum/CGRP/HO-1/prognosis分类
医药卫生引用本文复制引用
李凤敏..降钙素基因相关肽及血红素氧合酶-1对反流性食管炎病情评估及预后的价值分析[J].食管疾病,2024,6(4):288-291,300,5.
