实用妇产科杂志2024，Vol.40Issue(11)：918-922,5.
环孢素A在不明原因反复种植失败患者中的应用研究
Study on the Application of Cyclosporine A in Patients with Unexplained Re-peated Implantation Failure
摘要
Abstract
Objective:To investigate the clinical efficacy of Cyclosporine A(CsA)in patients with unexplained repeated implantation failure(URIF),and to analyze the changes of peripheral blood lymphocyte subsets after CsA treatment.Methods:105 patients with URIF who underwent frozen-thawed embryo transfer(FET)in the De-partment of Reproductive Medicine in The Second Affiliated Hospital of Kunming Medical University from Septem-ber 30,2021 to March 1,2022 were selected.After informed consent,the patients were divided into CsA group(n=52)and control group(n=53)according to whether they received CsA treatment or not.Pregnancy outcomes and changes in lymphocyte subset were compared between the two groups.Results:The embryo implantation rate and clinical pregnancy rate in CsA group were higher than those in the control group,the difference was statisti-cally significant(48.91%vs.32.56%,P=0.027;53.85%vs.32.08%,P=0.024).The CsA group had a lower ear-ly abortion rate than the control group(10.71%vs.23.53%),but the difference was not statistically significant(P=0.25).The percentage of CD3-CD16+CD56+in CsA group was significantly decreased after treatment[(16.15±5.37)%vs.(18.23±7.10)%,P=0.012],it was also lower than that in the control group[(16.15±5.37)%vs.(18.67±5.16)%,P=0.018].Conclusions:CsA treatment can significantly improve the clinical preg-nancy rate and embryo implantation rate of frozen-thawed embryo transfer in patients with URIF,which may be a-chieved by promoting the distribution of peripheral blood lymphocytes to the direction of embryo implantation,es-pecially by down-regulating the percentage of CD3-CD16+CD56+.CsA has a certain application prospect in the field of assisted reproduction.关键词
环孢素A/不明原因反复种植失败/临床妊娠率/胚胎种植率/淋巴细胞亚群Key words
Cyclosporine A/Unexplained repeated implantation failure/Clinical pregnancy rate/Embryo im-plantation rate/Lymphocyte subsets分类
医药卫生引用本文复制引用
王艺璇,宋家美,别嘉,苏娅,陈静思,汪宗玉,孟昱时..环孢素A在不明原因反复种植失败患者中的应用研究[J].实用妇产科杂志,2024,40(11):918-922,5.基金项目
云南省"万人计划"名医专项人才项目(编号:云卫人发[2019]35) （编号:云卫人发[2019]35）
云南省教育厅科学研究基金项目(编号:2022J0240) （编号:2022J0240）
