石油化工2024，Vol.53Issue(12)：1827-1835,9.DOI:10.3969/j.issn.1000-8144.2024.12.020
分子杂交策略设计的喹诺酮类抗菌化合物进展
Progress in the design of quinolone antibacterial compounds based on molecular hybridization strategy
宋润喆 1郑刚1
作者信息
- 1. 中石化(北京)化工研究院有限公司,北京 100013
- 折叠
摘要
Abstract
Quinolone compounds are widely used in the clinical treatment of bacterial infections,and some quinolone derivatives are the first choice for treating specific infections.With the long-term use of antibacterial agents,it is necessary to develop antibacterial agents with new structures.The molecular hybridization strategy was adopted to combine two bioactive fragments to obtain new compounds with higher target activities or multiple targets to improve the overall activities of agents in vivo to the disease and achieve better effects.This paper reviewed the mechanism of action and structure-activity relationship of quinolones,the progress in novel quinolone antibacterial compounds obtained by the molecular hybridization strategy,and the research progress in the optimization of quinolone antibacterial compounds.关键词
喹诺酮类/抗菌/分子杂交Key words
quinolone/antibacterial/molecular hybridization分类
化学化工引用本文复制引用
宋润喆,郑刚..分子杂交策略设计的喹诺酮类抗菌化合物进展[J].石油化工,2024,53(12):1827-1835,9.
