中国医疗设备2024，Vol.39Issue(12)：28-32,5.DOI:10.3969/j.issn.1674-1633.2024.12.006
心脏常温机械灌注装置的研制
Development of Heart Normothermic Machine Perfusion Device
摘要
Abstract
Objective To introduce a heart normothermic machine perfusion device to achieve in vitro preservation of transplanted hearts.Methods The peristaltic pumps and membrane oxygenators were utilized to simulate an artificial heart and lung.The solution of infusing normothermic blood perfusate to the transplanted heart was used to achieve rhythmic beating and long-term preservation of the transplanted heart in vitro.At the same time,The cardiac perfusion status was determined by the lactate level of the perfusate,and the cardiac perfusion flow and pressure were monitored in real-time.Results The device parameters met the necessary requirements,and it had been used for in vitro perfusion experiments in Chinese miniature porcine hearts(n=3).The results showed that the heart was well paced in vitro,which preliminary validated its feasibility.Conclusion Normothermic machine perfusion provides a novel strategy for heart preservation and is expected to extend the preservation time of the heart in vitro and expand the number of potential donor organs.关键词
心脏保存/常温机械灌注/离体灌注/心脏移植/设备研发/器官评估Key words
heart preservation/normothermic machine perfusion/in vitro perfusion/heart transplantation/equipment research/organ evaluation分类
医药卫生引用本文复制引用
刘倩,刘雯雁,赵长缨,闫炀,王飞扬,郑幸龙..心脏常温机械灌注装置的研制[J].中国医疗设备,2024,39(12):28-32,5.基金项目
陕西省重点研发计划(2023-YBSF-482). （2023-YBSF-482）
