贺氏火针联合核桃壳灸治疗围绝经期干眼的临床观察OA北大核心CSTPCDMEDLINE

Objective To observe the clinical effect on perimenopausal dry eye disease treated with He's fire needle therapy combined with walnut-shell moxibustion.Methods A total of 60 patients with perimenopausal dry eye disease were randomized into an observation group(30 cases)and a control group(30 cases).In the observation group,the pricking technique with fire needle was operated at bilateral Naokong(GB19),Feishu(BL13),Xinshu(BL15),Ganshu(BL18),Pishu(BL20),Shenshu(BL23),3 times a week,for 4 weeks,and the walnut-shell moxibustion was combined,30 minutes each time,3 times a week,for 4 weeks.In the control group,hyaluronic acid sodium eye drops were used,one drop each time,3 times a day,for 4 weeks.Before and after treatment,the scores of the questionnaire for dry eye disease in China,the result of lacrimal secretion test(Schimer Ⅰ test,SⅠT)and tear film break-up time(BUT),as well as the modified Kupperman score were evaluated in the two groups.The clinical effect was compared between the two groups.Results After 4 weeks of treatment,the results of SⅠT and BUT increased(P<0.001),while the scores of the questionnaire for dry eye disease in China,the modified Kupperman score decreased(P<0.001)in the two groups when compared with the baseline.In the observation group,the result of SⅠT and BUT were higher than those of the control group(P<0.05),while the scores of the questionnaire for dry eye disease in China,and the modified Kupperman score was lower(P<0.05).The marked effective rate(30/60,50.0%)in the observation group was better than that(10/60,16.7%)of the control group(P<0.05).Conclusion In treatment of perimenopausal dry eye disease,the combined therapy of fire needling and walnut-shell moxibustion obtains the superior effect to hyaluronic acid sodium eye drops.This combined therapy can effectively relieve the eye symptoms,increase the secretion of tears,prolong BUT,and ameliorate systemic symptoms.