针刺研究2024，Vol.49Issue(12)：1325-1332,8.DOI:10.13702/j.1000-0607.20240310
针刺调控细胞程序性死亡治疗脊髓损伤的研究进展
Progress of researches on acupuncture treatment of spinal cord injury by regulating programmed cell death
摘要
Abstract
Spinal cord injury(SCI)is a highly disabling disease of the central nervous system,and seriously affects the patients'quality of life.A large number of studies have shown that programmed cell death(PCD)is an important pathological mechanism of secondary injury in SCI.As a non-drug therapy,acupuncture therapy has the characteristics of bidirectional,holistic and multi-level actions,which can target PCD pathways to play a neuroprotective effect,and has great potential in regulating PCD in the treatment of SCI.In the present paper,we systematically elaborated the PCD pathway related to SCI and summed up the possible mechanism of acupuncture underlying improvement of SCI from 1)regulating apoptosis,2)modulating autophagy,3)regulating pyroptosis,4)inhibiting ferroptosis,and 5)suppressing necroptosis.These may provide a theoretical basis for acupuncture treatment of SCI and for further research in the coming years.关键词
脊髓损伤/针刺/细胞程序性死亡/综述Key words
Spinal cord injury/Acupuncture/Programmed cell death/Review引用本文复制引用
韩名媛,曹馨元,杨成妍,高睿泽,吕晓琳,孙忠人,范颖,尹洪娜..针刺调控细胞程序性死亡治疗脊髓损伤的研究进展[J].针刺研究,2024,49(12):1325-1332,8.基金项目
国家自然科学基金面上项目(No.81873378) （No.81873378）
黑龙江省博士后面上项目(No.LBH-Z19211) （No.LBH-Z19211）
哈尔滨市科技局科技计划自筹经费项目(No.2022ZCZJNS066) （No.2022ZCZJNS066）
