Association of handgrip strength with aortic stenosis among adults aged 60 years and older:evidence from the 157097 UK Biobank participantsOA
Objective To examine the association of handgrip strength with aortic stenosis incidence among adults aged 60 years and older.Methods We conducted a cohort study using the UK Biobank data to assess the relationship between handgrip strength and incident aortic stenosis in individuals aged 60 years and older.Handgrip strength was measured using a Jamar J00105 hydraulic hand dynamometer.Adjusted Cox proportional hazards regression models were conducted to assess the association between handgrip strength and incident aortic stenosis.Results We included 157,097 UK Biobank participants(78,151 women and 78,946 men)in our study,with mean age of 64±2.9 years.During a median follow-up of 8.1(7.4–8.8)years,1543(1.0%)participants developed incident aortic stenosis.Compared with those with the lowest handgrip strength(tertile 1),the adjusted hazard ratios(95%confidence interval)of incident aortic stenosis in the middle(tertile 2)and the highest(tertile 3)were 0.86(0.77–0.97)and 0.76(0.67–0.87),respectively.Conclusions Higher handgrip strength was associated with lower risk of developing aortic stenosis in older adults.Future studies warrant preventive strategies for older adults with lower handgrip strength.
Cheng-Xiang SONG;Qing LI;Cong-Ying XIA;Lu LONG;Xiao-Xi ZENG;Jun-Li LI;Mao CHEN
Laboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China Department of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,ChinaLaboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China National Clinical Research Center for Geriatrics,the Center of Gerontology and Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan Province,ChinaDepartment of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,ChinaDepartment of Epidemiology and Health Statistics,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan Province,ChinaWest China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China Division of Nephrology,Kidney Research Institute,West China hospital,Sichuan University,Chengdu,Sichuan Province,ChinaLaboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,ChinaLaboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China Department of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China
临床医学
stenosisaorticstrength
《Journal of Geriatric Cardiology》 2024 (11)
P.1026-1033,8
funded by UK Research and Innovation(grant ref:MC_PC_20029 and MC_PC_20058).
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