北京中医药大学学报2024，Vol.47Issue(12)：1661-1667,7.DOI:10.3969/j.issn.1006-2157.2024.12.005
从肝郁脾虚与线粒体自噬的相关性探讨中枢疲劳的病理机制
Exploration on the pathological mechanism of central fatigue from the correlation between liver stagnation and spleen deficiency and mitophagy
摘要
Abstract
Central fatigue refers to the central nervous system disease caused by excessive mental pressure or excessive physical activity,which shows a series of fatigue symptoms.The pathological mechanism of central fatigue remains unclear,and the mitochondrial quality control pathway represented by mitophagy is closely related to the occurrence and development of central fatigue.Traditional Chinese medicine considers liver stagnation and spleen deficiency as the key pathogenesis of central fatigue.This paper suggests that oxidative stress may be an important basis for the occurrence of central fatigue,energy metabolism disorders are specific manifestations of liver's failure of conveyance and dispersion and spleen's failure of healthy transportation,and the abnormal accumulation of reactive oxygen can be regarded as pathological products of central fatigue.Therefore,based on oxidative stress and energy metabolism,the pathologic mechanism of liver's failure of conveyance and dispersion and spleen's failure of healthy transportation in central fatigue from the perspective of mitophagy has a rich theoretical connotation,and provides a theoretical reference for the clinical treatment of central fatigue.关键词
中枢疲劳/线粒体自噬/肝郁脾虚/氧化应激/能量代谢Key words
central fatigue/mitophagy/liver depression and spleen deficiency/oxidative stress/energy metabolism分类
医药卫生引用本文复制引用
张翼飞,于清茜,施晴寰,兰碧娟,张泽涵,李峰..从肝郁脾虚与线粒体自噬的相关性探讨中枢疲劳的病理机制[J].北京中医药大学学报,2024,47(12):1661-1667,7.基金项目
国家自然科学基金面上项目(No.81874428) （No.81874428）
国家自然科学基金青年科学基金项目(No.82204978) National Natural Science Foundation of China(Nos.81874428 and 82204978) （No.82204978）
