磁共振成像2024，Vol.15Issue(11)：32-38,7.DOI:10.12015/issn.1674-8034.2024.11.006
MOLLI T1 mapping定量技术在儿童脑发育评估中的应用可行性探讨
Application of MOLLI T1 mapping quantitative technology in the assessment of pediatric brain development
摘要
Abstract
Objective:To explore the value of the modified Look-Locker inversion recovery(MOLLI)T1 mapping quantitative technique in evaluating the development of brain in children quantitatively.Materials and Methods:Fifty-three children with normal head magnetic resonance imaging results were included,and optimized MOLLI and magnetization prepared 2 rapid acquisition gradient echoes(MP2RAGE)sequences were used to perform T1 mapping quantitative analysis on 36 brain regions of each subject.We evaluate the consistency of T1 values in each brain region obtained from two sequences,compared the differences in T1 values in each brain region of the two sequences,and analyze the correlation between T1 values in each brain region of the two sequences and age.Results:The intraclass correlation co-efficient(ICC)for the MOLLI sequence and MP2RAGE sequence in all brain regions were greater than 0.8(P＜0.001),except for the bilateral dorsal pontine and cerebral peduncle.The differences in T1 values between the two sequences in each brain region were statistically significant(P＜0.05,FDR-corrected),the T1 values in each brain region of the MOLLI group were higher than those in the MP2RAGE group.The T1 values of each brain region in both sequences were negatively correlated with age(P＜0.001).Conclusions:The optimized MOLLI sequence can be used for the quantitative evaluation of brain development in children,showing good consistency with MP2RAGE sequence,and accurately quantifying T1 values of brain regions,providing a new sequence selection for the study of the nervous system of fetuses and children.关键词
脑发育/儿童/磁共振成像/改良回顾反转恢复序列/T1 mapping/髓鞘Key words
brain development/children/magnetic resonance imaging/modified Look-Locker inversion recover sequence/T1 mapping/myelin sheath分类
医药卫生引用本文复制引用
杨雪,贾凤林,马鑫茂,李学胜,李珮,张露,廖怡,宁刚,曲海波..MOLLI T1 mapping定量技术在儿童脑发育评估中的应用可行性探讨[J].磁共振成像,2024,15(11):32-38,7.基金项目
国家重点研发计划项目(编号:2018YFC1002200) （编号:2018YFC1002200）
四川省自然科学基金项目(编号:2022NSFSC0830) National Key Research and Development Program of China(No.2018YFC1002200) （编号:2022NSFSC0830）
Natural Science Foundation of Sichuan Province(No.2022NSFSC0830). （No.2022NSFSC0830）
