磁共振成像2024，Vol.15Issue(11)：142-147,6.DOI:10.12015/issn.1674-8034.2024.11.022
阿尔茨海默病患者血浆标志物及其与磁共振脑影像和认知功能关联的研究进展
Research progress of plasma biomarkers and the association with MRI neuroimaging and cognitive function in patients with Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is the most common type of dementia,and is characterized by the deposition of amyloid plaques and neurofibrillary tangles in the brain,leading to progressive cognitive decline.Plasma biomarkers reflect the characteristics and severity of AD pathological changes in the brain.In addition,with the development of neuroimaging technology,MRI can clarify the specific patterns of neuronal changes in AD pathology.Both of them play increasingly important roles in the early diagnosis of AD.This article reviews the main plasma biomarkers of AD and their association with MRI neuroimaging and cognitive function,with the aim of offering a novel perspective for the diagnosis,prediction and pathological mechanism understanding of AD.关键词
阿尔茨海默病/血浆生物标志物/神经影像/磁共振成像/认知功能Key words
Alzheimer's disease/plasma biomarkers/neuroimaging/magnetic resonance imaging/cognitive function分类
医药卫生引用本文复制引用
葛丹妮,陈夫涛,陈玖,张鑫,张冰..阿尔茨海默病患者血浆标志物及其与磁共振脑影像和认知功能关联的研究进展[J].磁共振成像,2024,15(11):142-147,6.基金项目
科技创新2030—"脑科学与类脑研究"重大项目(编号:2022ZD0211800) National Science and Technology Innovation 2030_Major Program of"Brain Science and Brain-Like Research"(No.2022ZD0211800). （编号:2022ZD0211800）
