磁共振成像2024，Vol.15Issue(11)：160-168,9.DOI:10.12015/issn.1674-8034.2024.11.025
阻塞性睡眠呼吸暂停患者脑结构及功能磁共振成像研究进展
The progress of brain structural and functional magnetic resonance imaging in patients with obstructive sleep apnea
摘要
Abstract
Obstructive sleep apnea(OSA)is the most common sleep disorder with abnormal brain structure and function,leading to a complication of cognitive impairment.In recent years,MRI has been flourishing,including voxel based morphometry(VBM),diffusion tensor imaging(DTI),diffusion tensor imaging analysis along the perivascular space(DTI-ALPS),diffusion kurtosis imaging(DKI),resting state functional magnetic resonance imaging(rs-fMRI),arterial spin labeling(ASL),magnetic resonance spectroscopy(MRS).Especially newly emerging DTI-ALPS and DKI techniques have provided a more novel perspective and broader field of view.DTI-ALPS can evaluate the function of the cerebral lymphatic system non-invasively and reveal the mechanism of lymphatic metabolism disorders in OSA patients,which provide a new perspective for the pathological and physiological mechanism of OSA patients,and provide new ideas for the improvement of treatment plans.DKI could demonstrate microstructural abnormalities of the brain more sensitively before changes might be found with conventional imaging,that provide a basis for earlier diagnosis and treatment of OSA patients.This article reviews the progress of cerebral structural and functional magnetic resonance imaging of OSA patients in recent years,aiming to reveal their neuroimaging changes and pathophysiological mechanisms,and to provide basis for early diagnosis,treatment,and improvement of treatment plans for OSA patients.关键词
阻塞性睡眠呼吸暂停/磁共振成像/静息态功能磁共振成像/沿血管周围间隙扩散张量成像分析/扩散峰度成像/类淋巴系统Key words
obstructive sleep apnea/magnetic resonance imaging/resting state functional magnetic resonance imaging/diffusion tensor imaging analysis along the perivascular space/diffusion kurtosis imaging/glymphatic system分类
医药卫生引用本文复制引用
孙利强,李琳,胡婧,刘丽莹,崔凯歌,杨冀萍,贾娟,于佳琪..阻塞性睡眠呼吸暂停患者脑结构及功能磁共振成像研究进展[J].磁共振成像,2024,15(11):160-168,9.基金项目
河北省重点研发计划项目(编号:21377784D) （编号:21377784D）
河北省卫生健康委员会医学科学研究重点课题计划项目(编号:20160123、20150681) （编号:20160123、20150681）
河北省2023年政府资助临床医学优秀人才培养项目(编号:ZF2023149) Key R&D Program Project of Hebei Province(No.21377784D) （编号:ZF2023149）
Key Project of Medical Science Research of Hebei Provincial Health Commission(No.20160123,20150681) （No.20160123,20150681）
Government Funded Clinical Medicine Excellent Talent Training Project of Hebei Province in 2023(No.ZF2023149). （No.ZF2023149）
