心脑血管病防治2024，Vol.24Issue(11)：10-13,4.DOI:10.3969/j.issn.1009-816x.2024.11.003
抗阻运动对冠心病患者运动耐量及血管内皮调节因子的影响
Effects of resistance exercise on exercise tolerance and vascular endothelial regulatory factors in patients with coronary artery disease
摘要
Abstract
Objective To investigate the effects of resistance exercise on exercise tolerance and vascular endothelial regulatory factors in patients with stable coronary artery disease(CHD).Methods A prospective cohort study was conducted,including 100 patients with stable CHD from October 2020 to October 2022 at the Second Affiliated Hospital of Baotou Medical College.Patients were randomly divided into a control group and a resistance exercise group,with a final study population of 77 patients,consisting of 36 in the control group and 41 in the resistance exercise group.The control group received standardized drug treatment,while the resistance exercise group performed low-intensity resistance exercise for 12 weeks according to an exercise prescription in addition to standardized drug treatment.The 6-minute walk distance was used to assess exercise tolerance,and ELISA was used to measure the levels of vascular endothelial growth factor(VEGF),nitric oxide(NO),and endothelin-1 in peripheral blood.The 6-minute walking distance,levels of VEGF,NO,and endothelin-1 were compared before and after 12 weeks of treatment in both groups.The incidence of serious cardiovascular adverse events was compared between the two groups after a 24-week follow-up.Results(1)Compared with before exercise,the 6-minute walking distance increased,while the resting systolic blood pressure and the resting diastolic blood pressure decreased in the resistance exercise group(t=7.538,2.290,2.639;P<0.05);VEGF and NO increased,while endothelin-1 decreased in the resistance exercise group(t=5.509,6.089,5.824;P<0.05).(2)Compared with the control group,the resistance exercise group had increased 6-minute walking distance,increased VEGF and NO levels,and decreased endothelin-1 level(t=3.504,3.559,3.502,3.645;P<0.05)after 12 weeks.(3)The difference in 6-minute walking distance before and after exercise in the resistance exercise group was positively correlated with the difference in VEGF and NO(r=0.385,0.485;P<0.05),and negatively correlated with the difference in endothelin-1(r=-0.510,P<0.01).(4)After a 24-week follow-up,there was no statistically significant difference in the incidence of serious cardiovascular adverse events between the two groups of CHD patients(8.33%vs.9.76%,P>0.05).Conclusion Low-intensity resistance exercise can increase the levels of VEGF and NO,decrease the level of endothelin-1,and improve the exercise tolerance of patients with stable CHD.关键词
抗阻运动/冠心病/6min步行距离/血管内皮生长因子/一氧化氮/内皮素-1Key words
Resistance exercise/Coronary heart disease/6-minute walking distance/Vascular endothelial growth factor/Nitric oxide/Endothelin-1引用本文复制引用
王孺贤,王增帅,刘雅楠,李玉兰..抗阻运动对冠心病患者运动耐量及血管内皮调节因子的影响[J].心脑血管病防治,2024,24(11):10-13,4.基金项目
内蒙古自治区自然科学基金项目(2021LHMS08011) （2021LHMS08011）
2022年度自治区卫生健康科技计划项目(202202255) （202202255）
