心脑血管病防治2024，Vol.24Issue(11)：28-31,4.DOI:10.3969/j.issn.1009-816x.2024.11.007
原发性高血压患者内皮抑素和基质裂解素2表达水平及临床意义分析
Expression levels and clinical significance of endostatin and suppression of tumorigenicity-2 in patients with essential hypertension
摘要
Abstract
Objective To investigate the expression levels of endostatin and suppression of tumorigenicity-2(ST2)in patients with essential hypertension and their clinical significance.Methods A total of 115 essential hypertension patients admitted to Changshu First People's Hospital from September 2020 to February 2022 were selected as the observation group.Another 115 healthy indivduals undergoing physical examination were selected as the control group.The general data and serum levels of endostatin,ST2 and nitric oxide(NO)in the observation group and control group were compared.The relationships between serum levels of endostatin,ST2,NO,diastolic blood pressure(DBP),systolic blood pressure(SBP),and urine microalbumin in essential hypertension patients were analyzed.The influencing factors for the occurrence of essential hypertension were also analyzed.Results The DBP,SBP,urine microalbumin,serum endostatin and ST2 in the observation group were higher than those in the control group,while the level of NO was lower,there were statistically significant differences(t=29.882,35.966,40.670,12.838,16.792,15.507;P<0.05).The levels of serum endostatin and ST2 in essential hypertension patients were negatively correlated with NO(r=-0.504,-0.556;P<0.05)and positively correlated with DBP,SBP,and urine microalbumin(r=0.517,0.450,0.485,0.503,0.548,0.446;P<0.05).Multivariate Logistic regression analysis indicated that endostatin,ST2,and NO were influencing factors for the occurrence of essential hypertension(OR=2.593,2.434,0.646;P<0.05).Conclusion The levels of serum endostatin and ST2 in essential hypertension patients are higher,both of them are related to the endothelial function indicator NO and are influencing factors for essential hypertension.关键词
内皮抑素/基质裂解素2/一氧化氮/原发性高血压Key words
Endostatin/Suppression of tumorigenicity-2/Nitric oxide/Essential hypertension引用本文复制引用
王志松,刘波,韩冷..原发性高血压患者内皮抑素和基质裂解素2表达水平及临床意义分析[J].心脑血管病防治,2024,24(11):28-31,4.基金项目
常熟市卫生健康委员会科技计划项目(csws202006) （csws202006）
