巴楚医学2024，Vol.7Issue(4)：54-61,8.DOI:10.3969/j.issn.2096-6113.2024.04.006
心通制剂"异病同治"冠心病和糖尿病的作用机制研究
Mechanism of the"Same Treatment of Different Diseases"of Xintong Preparation for Coronary Heart Disease and Diabetes Mellitus
摘要
Abstract
Objective:Guided by the traditional Chinese medicine concept of"treating different diseases with the same method,"this study utilizes network pharmacology and molecular docking techniques to analyze the pharmacological mechanisms of action of Xintong preparations in the treatment of coronary heart disease and diabetes.Methods:The chemical components of the Xintong preparation were retrieved from the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database and literature searches.Drug targets were obtained using SwissTargetPrediction,and targets for coronary heart disease and diabetes were retrieved from the GeneCards database and TTD database.The"drug-component-target"network diagram was constructed using Cytoscape 3.9.1.The protein-protein interaction(PPI)network was constructed using the STRING database,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed using the DAVID database.Finally,molecular docking was conducted.Results:A total of 90 potential active ingredients were screened out for the treatment of coronary heart disease and diabetes by Xintong preparations,corresponding to 121 targets.Analysis of the drug-component-target network diagram identified the main active components,including quercetin,astragaloside Ⅳ,emodin,icariin,and ferulic acid.PPI network analysis identified key targets,including signal transducer and activator of transcription 3(STAT3),tumor protein p53(TP53),tumor necrosis factor(TNF),serine/threonine-protein kinase 1(AKT1),interleukin-6(IL-6),and vascular endothelial growth factor A(VEGFA).Molecular docking results showed that the key components had good binding capabilities with the core targets.Conclusion:Multiple active components in Xintong preparations exert the effects of"treating different diseases with the same method"for coronary heart disease and diabetes through multiple targets and pathways,providing new insights and theoretical basis for further experimental and clinical research.关键词
异病同治/心通制剂/冠心病/糖尿病/网络药理学Key words
same treatment of different disease/Xintong preparation/coronary heart disease/diabetes mellitus/network pharmacology分类
医药卫生引用本文复制引用
申凤霞,唐云峰,赵利枝,严琴琴,周冰,马云,李倩,关永霞,范建伟..心通制剂"异病同治"冠心病和糖尿病的作用机制研究[J].巴楚医学,2024,7(4):54-61,8.基金项目
山东省重点研发计划(重大科技创新工程)项目(No:2021CXGC010508) （重大科技创新工程）
