巴楚医学2024，Vol.7Issue(4)：74-78,5.DOI:10.3969/j.issn.2096-6113.2024.04.009
儿童潜伏性结核感染筛查及预后分析
Screening and Prognosis Analysis of Latent Tuberculosis Infection in Children
摘要
Abstract
Objective:To analyze the screening and prognosis of latent tuberculosis infection(LTBI)in children with different systemic diseases.Methods:A retrospective study was conducted to collect 484 children who underwent tuberculosis infection T-cell spot test(T-SPOT.TB)at Yichang Central People's Hospital from January 2018 to April 2022.The children were divided into T-SPOT positive group(n=27)and T-SPOT negative group(n=457)based on the results of T-SPOT.TB examination,and the included children were followed up and observed.Results:Among the 484 children screened for LTBI,27 were positive,with a total positive rate of 5.58％.There were statistical differences between the two groups in different systemic diseases and whether they were tuberculosis patients(both P＜0.05).The highest proportion of children in both groups was respiratory system diseases(59.26％and 79.65％).Among children with different systemic diseases,the T-SPOT positive rate was highest in blood system disease and tumor(23.81％),followed by lymphatic system(14.29％),nervous system(7.69％),digestive system(6.67％),respiratory system(4.21％),and rheumatologic immune system(3.70％).Nine children were diagnosed with tuberculosis,and there was no significant difference in whether they were in close contact with tuberculosis patients and related blood indicators between tuberculosis patients and non-tuberculosis patients(both P＜0.05).Conclusion:Children with blood system disease and tumor,lymphatic,nervous,and digestive system diseases have higher detection rates of LTBI than those with respiratory and rheumatologic immune system diseases.These children need to actively undergo LTBI screening.关键词
结核分枝杆菌/潜伏性结核感染/筛查/结核感染T细胞斑点试验Key words
Mycobacterium tuberculosis/latent tuberculosis infection(LTBI)/screening/T cell spot test for tuberculosis infection(T-SPOT.TB)分类
医药卫生引用本文复制引用
谢莹莹,芦伟..儿童潜伏性结核感染筛查及预后分析[J].巴楚医学,2024,7(4):74-78,5.基金项目
湖北省儿科联盟科学基金项目(No:HBPAMR-2021-16) （No:HBPAMR-2021-16）
