北华大学学报（自然科学版）2025，Vol.26Issue(1)：76-79,4.DOI:10.11713/j.issn.1009-4822.2025.01.013
VSD联合胰岛素、庆大霉素、维生素B12对糖尿病足创面及组织中Bcl-2/Bax水平的影响
Effects of VSD Combined with Insulin,Gentamicin,and Vitamin B12 on Bcl-2/Bax Levels in Diabetic Foot Wounds and Tissues
摘要
Abstract
Objective To investigate the effect of vacuum sealing drainage(VSD)combined with insulin,gentamicin and vitamin B12 irrigation on levels of Bcl-2 and Bax in the wound surface and tissue of diabetes foot.Methods 55 patients with diabetic foot were selected as study subjects,and they were divided into control group(20 cases,applying VSD to treat diabetic foot wounds),and the experimental group(35 cases,applying VSD combined with insulin,gentamicin,and vitamin B12 to flush the wound surface of diabetes foot)according to different treatment methods.The wound area and the levels of Bcl-2 and Bax in the wound tissue of two groups were compared 7 days and 14 days after treatment.Results There was no significant difference in the wound surface of two groups 7 days after treatment(P>0.05),and there was no significant difference in the expression level of Bax between experimental group and control group(P>0.05).The level of Bcl-2 in experimental group was significantly higher than that in control group(P<0.05).After 14 days of treatment,the wound area in experimental group was significantly smaller than that in control group(P<0.05),and there was no significant difference in Bax levels compared to control group(P>0.05).Bcl-2 levels were significantly higher than those in control group(P<0.05),and the Bcl-2/Bax ratio was significantly higher than that in control group(P<0.05).Conclusion The mechanism of action of VSD combined with insulin,gentamicin,and vitamin B12 rinse for the treatment of diabetic foot wounds involves up-regulating the Bcl-2 levels in the wound tissue by activating the Bcl-2-mediated anti-apoptotic pathway and increasing the Bcl-2/Bax ratio.This approach aims to inhibit local apoptosis and promote wound healing.关键词
负压封闭引流/糖尿病足/Bcl-2/BaxKey words
negative pressure closed drainage/diabetes foot/Bcl-2/Bax分类
临床医学引用本文复制引用
杨威,谭淑丹,朱春雷,赵维彦,邱旭东,陈烨,孙雁..VSD联合胰岛素、庆大霉素、维生素B12对糖尿病足创面及组织中Bcl-2/Bax水平的影响[J].北华大学学报（自然科学版）,2025,26(1):76-79,4.基金项目
吉林省卫生健康科技能力提升项目(2023LC028). （2023LC028）
