成都大学学报（自然科学版）2024，Vol.43Issue(4)：337-343,7.DOI:10.3969/j.issn.1004-5422.2024.04.001
基于药效作用值的茵栀黄颗粒及口服液质量再评价研究
Re-Evaluation of Yinzhihuang Granules and Oral Liquid Quality Based on Pharmacodynamic Value
摘要
Abstract
The quality of Yinzhihuang oral liquid and granules will be re-evaluated with the pharmacody-namic value as the index.The active ingredient content wogomin,chlorogenic acid and gardenin were de-termined by using HPLC.Analytic hierarchy process method was also used to evaluate the pharmacodyna-mic effects of Yinzhihuang oral liquid and granules.The efficacy of these two preparations was verified u-sing anti-inflammatory,analgesic,and hepatoprotective pharmacodynamic models.The Yinzhihuang Oral Liquid and Yinzhihuang Granules exhibited anti-inflammatory effects of 20.54 and 20.61 mg,respective-ly,the analgesic effects were 14.37 and 13.66 mg,respectively,and the pharmacodynamic effects on he-patic protection were 28.54 and 24.07 mg,respectively.The in vivo efficacy studies of this research indi-cate that Yinzhihuang Oral Liquid provides liver protection and has a stronger analgesic effect than Yinzhihuang Granules.Additionally,the anti-inflammatory effect of Yinzhihuang Granules was found to be stronger than that of Yinzhihuang Oral Liquid.These results are consistent with the predicted pharmacody-namic values.The pharmacodynamic value can be used as an index for the re-evaluation of the pharmaco-dynamic effect of Yinzhihuang series preparations.关键词
茵栀黄系列制剂/药效作用值/抗炎/镇痛/护肝Key words
Yinzhihuang series preparation/pharmacodynamic effects/anti-inflammatory/analgesic/hepa-toprotective分类
医药卫生引用本文复制引用
吴磊,刘钱,刘晓风,彭悠,王渝凯,李琪如,沈芃..基于药效作用值的茵栀黄颗粒及口服液质量再评价研究[J].成都大学学报（自然科学版）,2024,43(4):337-343,7.基金项目
四川省2021-2023年高等教育人才培养质量和教学改革项目(JG2021-1106) （JG2021-1106）
成都大学2021-2023年研究生人才培养质量和教学改革立项项目(cdjgy2022004) （cdjgy2022004）
乐山职业技术学院校级课题(KY2023034) （KY2023034）
成都大学国家级大学生创业训练计划项目(202411079006S) （202411079006S）
四川省抗病毒中药产业化工程技术研究中心开放课题(KFKT24QM01) （KFKT24QM01）
