电化学(中英文)2024,Vol.30Issue(11):20-29,10.DOI:10.61558/2993-074X.3488
基于单细胞尺度的纳米移液管递送研究
Precision Delivery Using Nanopipette for Single-cell Studies
摘要
Abstract
Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology.In addition to the topographic imaging,its capability of localized delivery of bio-active molecules is emerging.In this mini review,we introduce the applications of nanopipette in single-cell researches with a focus on localized delivery.The working principles of three delivery modes including resistive pulse,pressure-driven flow,and electroosmotic flow-driven delivery are summarized and compared.Their applications in single-cell researches are reviewed.The current technical challenges in scanning ion conductance microscopy-based delivery,and their growing influence in medicine and pharmacologic researches are also discussed.关键词
扫描离子电导显微镜/纳米移液管/单细胞成像/局部递送Key words
Scanning ion conductance microscopy/Nanopipette/Single cell image/Local delivery引用本文复制引用
张鹤,Md Maksudur Rahman,陶洋,Joseph W Sampson,任航..基于单细胞尺度的纳米移液管递送研究[J].电化学(中英文),2024,30(11):20-29,10.基金项目
This work is funded by the National Institute of General Medical Sciences(1R35GM147172-01). (1R35GM147172-01)