靶向谷氨酰胺酶治疗组织纤维化的研究进展OA北大核心CSTPCD
Research progress of targeting glutaminase to treat tissue fibrosis
组织纤维化是多种慢性疾病致残、致死的重要原因之一,它的预防及治疗也是医学界的主要难题.肌成纤维细胞是组织纤维化进展过程中的核心作用细胞.谷氨酰胺分解代谢可为肌成纤维细胞的激活和增殖提供能量.谷氨酰胺酶是谷氨酰胺分解代谢过程中的关键酶和起始酶,对谷氨酰胺功能的实现起着至关重要的作用.本文介绍了谷氨酰胺酶在组织纤维化中的作用及相关信号通路.此外,分析了以谷氨酰胺酶为靶点的组织纤维化治疗策略.总之,谷氨酰胺酶有望成为治疗组织纤维化的关键靶点,本文旨在为组织纤维化的研究提供一定的参考.
Tissue fibrosis is one of the important causes of disability and mortality in various chronic diseases,and its preven-tion and treatment are also major challenges in the medical field.Myofibroblasts are the core involved in the progression of tissue fi-brosis.Glutaminolysis can provide energy for the activation and proliferation of myofibroblasts.Glutaminase is a key and initiating enzyme in the process of glutaminolysis and plays a crucial role in the realization of glutamine function.In this paper,the role of glutaminase in tissue fibrosis and related signaling pathways are introduced.In addition,the treatment strategies for tissue fibrosis targeting glutaminase are also analyzed.In conclusion,glutaminase is expected to be a key target for the treatment of tissue fibro-sis,and this paper aims to provide some reference for research on tissue fibrosis.
马晓丽;刘金颖;郭旺;岳燕勤;杨星元;卢冰鑫;胡振兴;罗晓英
郑州大学人民医院,河南省人民医院消化内科,河南 郑州 450003长江大学附属第一医院泌尿外科,湖北 荆州 434000
基础医学
组织纤维化谷氨酰胺酶谷氨酰胺分解代谢肌成纤维细胞治疗
Tissue fibrosisGlutaminaseGlutaminolysisMyofibroblastsTreatment
《海南医学院学报》 2024 (024)
1906-1912 / 7
This study is supported by the General Program of National Natural Science Foundation of China(82170637),the Excellent Youth Science Fund Project of Henan Provincial Natural Science Foundation(232300421052),and the Henan Province Young and Middle-aged Health Science and Technology Innovation Outstanding Youth Talent Training Project(YXKC2022021) 国家自然科学基金面上项目(82170637);河南省自然科学基金优秀青年科学基金项目(232300421052);河南省中青年卫生健康科技创新杰出青年人才培养项目(YXKC2022021)
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