海南医学院学报2024，Vol.30Issue(24)：1906-1912,7.DOI:10.13210/j.cnki.jhmu.20240911.003
靶向谷氨酰胺酶治疗组织纤维化的研究进展
Research progress of targeting glutaminase to treat tissue fibrosis
摘要
Abstract
Tissue fibrosis is one of the important causes of disability and mortality in various chronic diseases,and its preven-tion and treatment are also major challenges in the medical field.Myofibroblasts are the core involved in the progression of tissue fi-brosis.Glutaminolysis can provide energy for the activation and proliferation of myofibroblasts.Glutaminase is a key and initiating enzyme in the process of glutaminolysis and plays a crucial role in the realization of glutamine function.In this paper,the role of glutaminase in tissue fibrosis and related signaling pathways are introduced.In addition,the treatment strategies for tissue fibrosis targeting glutaminase are also analyzed.In conclusion,glutaminase is expected to be a key target for the treatment of tissue fibro-sis,and this paper aims to provide some reference for research on tissue fibrosis.关键词
组织纤维化/谷氨酰胺酶/谷氨酰胺分解代谢/肌成纤维细胞/治疗Key words
Tissue fibrosis/Glutaminase/Glutaminolysis/Myofibroblasts/Treatment分类
医药卫生引用本文复制引用
马晓丽,刘金颖,郭旺,岳燕勤,杨星元,卢冰鑫,胡振兴,罗晓英..靶向谷氨酰胺酶治疗组织纤维化的研究进展[J].海南医学院学报,2024,30(24):1906-1912,7.基金项目
This study is supported by the General Program of National Natural Science Foundation of China(82170637),the Excellent Youth Science Fund Project of Henan Provincial Natural Science Foundation(232300421052),and the Henan Province Young and Middle-aged Health Science and Technology Innovation Outstanding Youth Talent Training Project(YXKC2022021) 国家自然科学基金面上项目(82170637) （82170637）
河南省自然科学基金优秀青年科学基金项目(232300421052) （232300421052）
河南省中青年卫生健康科技创新杰出青年人才培养项目(YXKC2022021) （YXKC2022021）
