110例次不同主要诊断鼻咽癌住院患者检验危急值回顾性分析OACSTPCD

Objective To analyze and summarize the types and distribution of critical laboratory values in hospi-talized patients with nasopharyngeal carcinoma(NPC),exploring specific distributions and characteristics of critical val-ues across various primary diagnoses.The study further investigates safe clinical management strategies for advanced-stage NPC patients exhibiting critical values.Methods This retrospective cohort study included data from 110 instances of critical values from 78 NPC patients admitted to the Department of Otolaryngology at Guangdong Provincial People's Hospital between January 2021 and December 2023.The frequency and occurrence of critical values were calculated and categorized into three groups based on discharge diagnoses:radiation-induced osteonecrosis,recurrent malignant naso-pharyngeal tumor,and epistaxis.Statistical analysis was conducted using Fisher's exact test in SPSS 22.0,with P＜0.05 considered statistically significant.Results Among hospitalized NPC patients,critical values primarily consisted of multi-drug-resistant bacterial infections(38.18％),electrolyte imbalances(29.09％),abnormal blood counts(17.27％),and coagulation dysfunctions(8.18％).Statistically significant differences were observed in the occurrence of multidrug-resistant infections,electrolyte imbalances,and abnormal blood counts among patients with diagnoses of radiation-in-duced osteonecrosis and recurrent malignant nasopharyngeal tumors.Notably,16 patients experienced multiple critical val-ues during a single hospitalization,and 7 patients encountered recurrent critical values across separate hospitalizations for the same parameters.Conclusion Critical values in hospitalized NPC patients include multidrug-resistant infections,electrolyte imbalances,blood count abnormalities,and coagulation dysfunctions,with significant distribution differences across primary diagnoses.Patients experiencing multiple simultaneous critical values likely have severe disease conditions necessitating immediate intervention.Patients with radiation-induced osteonecrosis are at a higher risk for recurrent mul-tidrug-resistant infections during repeated hospitalizations,particularly those with recurrent malignant NPC.