广东医学2024，Vol.45Issue(12)：1628-1632,5.DOI:10.13820/j.cnki.gdyx.20241563
集束化护理干预措施对鼻咽癌放疗后口干症的影响
Effect of bundled nursing interventions on xerostomia in nasopharyngeal carcinoma patients after radiotherapy
摘要
Abstract
Objective To investigate the impact of bundled nursing interventions on the incidence of xerostomia in nasopharyngeal carcinoma(NPC)patients following radiotherapy.Methods A cohort study with a paired design was conducted on 200 NPC patients who received radiotherapy at the Department of Head and Neck Oncology,Jiangxi Cancer Hospital,from January 2022 to December 2023.Patients were divided into an intervention group(n=100)receiving bun-dled nursing care and a control group(n=100)receiving routine nursing care.The effectiveness and safety of the bundled nursing interventions in reducing radiotherapy-induced xerostomia were evaluated and analyzed.Results Clinical re-cords for all patients were complete and included in the statistical analysis.The incidence of radiotherapy-induced xeros-tomia was 41％in the intervention group compared to 55％in the control group,a statistically significant difference(x2=9.233,P=0.026).Subgroup analysis indicated that tumor N-stage and concurrent chemoradiotherapy were primary in-fluencing factors on xerostomia incidence between groups.Bundled nursing interventions significantly reduced xerostomia incidence in patients with high N-stage disease and those undergoing concurrent chemoradiotherapy(x2=12.469,P=0.005;x2=5.322,P=0.028).A significant reduction in high-grade xerostomia was also observed within the N-stage subgroup(x2=6.358,P=0.014).Moreover,the bundled nursing interventions effectively decreased the occur-rence of oral mucositis post-radiotherapy(x2=7.918,P=0.047).Conclusion Bundled nursing interventions can significantly reduce the incidence of xerostomia in high N-stage NPC patients and those undergoing concurrent chemora-diotherapy.Additionally,these interventions are beneficial in lowering the occurrence of oral mucositis,contributing to improved quality of life.关键词
集束化护理干预/鼻咽癌/口干症/放射治疗/生活质量Key words
bundled nursing interventions/nasopharyngeal carcinoma/xerostomia/radiotherapy/quality of life分类
医药卫生引用本文复制引用
熊娟,王超,万远婷..集束化护理干预措施对鼻咽癌放疗后口干症的影响[J].广东医学,2024,45(12):1628-1632,5.基金项目
江西省卫生与健康委员会科技计划项目(SKJP220219019) （SKJP220219019）
