广东医学2024，Vol.45Issue(12)：1633-1640,8.DOI:10.13820/j.cnki.gdyx.20242573
心肌细胞成熟障碍及其分子机制
Impaired maturation of cardiomyocytes and its molecular mechanisms
摘要
Abstract
The heart undergoes a dynamic maturation process from late embryonic stages to adulthood.However,in conditions such as cardiac disease or heart failure,cardiomyocytes tend to re-activate fetal gene expression,leading to morphological and functional maturation impairments that affect cardiac function.This review summarizes the manifesta-tions and molecular mechanisms of cardiomyocyte maturation impairment,focusing on the downregulation of adult sarcom-eric and cytoskeletal proteins,mitochondrial immaturity,reduced oxidative phosphorylation,and the dysregulation of pro-liferative transcriptional controls.Strategies to promote cardiomyocyte maturation,including regulation of energy substrates and metabolic processes,as well as inhibition of cell cycle re-entry,are discussed to provide theoretical support for un-derstanding heart failure mechanisms and improving treatment approaches.关键词
心肌细胞/成熟障碍/心力衰竭/能量代谢/增殖Key words
cardiomyocyte/maturation impairment/heart failure/energy metabolism/proliferation分类
医药卫生引用本文复制引用
杨露,肖建民,杨帆,陈灿,敖若晗,陈冬萍..心肌细胞成熟障碍及其分子机制[J].广东医学,2024,45(12):1633-1640,8.基金项目
东莞市社会发展科技项目(20231800940092) （20231800940092）
东莞市社会发展科技项目(20231800904382) （20231800904382）
