抗生素类新污染物的水质环境监测技术方法研究OACSTPCD

To serve the needs of water quality and environment monitoring of new antibiotics pollutants,a solid-phase extraction high-performance liquid chromatography triple quadrupole mass spectrometry method was established to simultaneously determine eight new antibiotic pollutants,including sulfonamides,quinolones,and macrolides,in environmental water.After enrichment and purification by solid-phase extraction,the water sample was separated and detected by high-performance liquid chromatography triple quadrupole mass spectrometry.Qualitative analysis was performed based on the retention time and characteristic ion peaks of the compounds,while quantitative analysis was performed using external standard method.The results showed that:①The target substance obtained effective baseline separation on liquid chromatography,with stable retention time,and the correlation coefficients R of the standard curve were all above 0.99 in the range of 20～200 ng/L.②The detection limits of 8 new antibiotics was between 0.65 and 3.12 ng/L According to the low concentration parallel addition test,the precision of the method was 4.3%～10.9%,and the recovery rate of the added standard was 65%～98%.The method established in this study had high sensitivity and good applicability,and can be used for the monitoring and analysis of sulfamethoxazole,sulfamethoxazole,sulfamethoxazole,sulfamethoxazole,ofloxacin,roxithromycin,and spiramycin in water quality environments.