环境保护科学2024，Vol.50Issue(6)：165-170,6.DOI:10.16803/j.cnki.issn.1004-6216.2023120008
抗生素类新污染物的水质环境监测技术方法研究
Water quality and environmental monitoring techniques for antibiotic based new pollutant
摘要
Abstract
To serve the needs of water quality and environment monitoring of new antibiotics pollutants,a solid-phase extraction high-performance liquid chromatography triple quadrupole mass spectrometry method was established to simultaneously determine eight new antibiotic pollutants,including sulfonamides,quinolones,and macrolides,in environmental water.After enrichment and purification by solid-phase extraction,the water sample was separated and detected by high-performance liquid chromatography triple quadrupole mass spectrometry.Qualitative analysis was performed based on the retention time and characteristic ion peaks of the compounds,while quantitative analysis was performed using external standard method.The results showed that:①The target substance obtained effective baseline separation on liquid chromatography,with stable retention time,and the correlation coefficients R of the standard curve were all above 0.99 in the range of 20～200 ng/L.②The detection limits of 8 new antibiotics was between 0.65 and 3.12 ng/L According to the low concentration parallel addition test,the precision of the method was 4.3%～10.9%,and the recovery rate of the added standard was 65%～98%.The method established in this study had high sensitivity and good applicability,and can be used for the monitoring and analysis of sulfamethoxazole,sulfamethoxazole,sulfamethoxazole,sulfamethoxazole,ofloxacin,roxithromycin,and spiramycin in water quality environments.关键词
新污染物/抗生素/固相萃取-高效液相色谱-三重四级杆质谱法/水质/环境监测Key words
new pollutants/antibiotics/solid phase extraction high-performance liquid chromatography triple quadrupole mass spectrometry/water quality/environmental monitoring分类
资源环境引用本文复制引用
魏莉,刘博,王铁龙,崔涤尘,张楠,刘嵩,李丹,王冬玲..抗生素类新污染物的水质环境监测技术方法研究[J].环境保护科学,2024,50(6):165-170,6.基金项目
辽宁省应用基础研究计划(青年专项)项目(2023JH2/101600011) （青年专项）
