分子影像学杂志2024，Vol.47Issue(12)：1277-1281,5.DOI:10.12122/j.issn.1674-4500.2024.12.01
18F-PI-2620 PET脑显像探究脑膜瘤大小与摄取的相关性
Correlation between meningioma size and tau uptake by 18 F-PI-2620 PET imaging
摘要
Abstract
Objective To explore the uptake of tau PET in meningioma by 18F-PI-2620 PET brain imaging,its correlation with lesion size and calcification,and its potential application.Methods A retrospective analysis was performed on 311 subjects who underwent 18F-PI-2620 PET brain examinations at our hospital from January 2020 to December 2023.Patients with meningioma diagnosed by final MRI enhancement were screened.The size and maximum standardized uptake value(SUVmax)of the meningioma lesions were measured for all included subjects,and the SUVmax of the lesion to the background(T/N)were obtained using the normal cerebral cortex on the opposite side as the background.Statistical analysis was performed using SPSS 26.0 statistical software,and the correlation between SUVmax,T/N values and lesion size and calcification was compared.Results Eight meningioma patients were included,including 3 males and 5 females,aged at 65-78(69.8±4.86)years old.There was a statistically significant difference in SUVmax between the meningioma and the background(P<0.05).The T/N in the meningioma group was higher than that of the background(P<0.001).There was no statistically significant difference in SUVmax and T/N ratio between the meningioma calcification group and the non-calcification group(P>0.05).The volume of the lesion was significantly correlated with the T/N ratio of uptake(R=0.89,P<0.01).Conclusion The tau uptake value of 18F-PI-2620 in meningioma is related to the size of the lesion,but not whether the lesion is calcified.关键词
脑膜瘤/tau蛋白质类/正电子发射断层显像术/18F-PI-2620Key words
meningioma/tau proteins/positron emission tomography/18F-PI-2620引用本文复制引用
朱胤琰,辛玫,张焱,王悦,万良荣,王成,黄钢,张晨鹏..18F-PI-2620 PET脑显像探究脑膜瘤大小与摄取的相关性[J].分子影像学杂志,2024,47(12):1277-1281,5.基金项目
国家重点研发计划(2020YFA0909000) （2020YFA0909000）
国家自然科学基金(82127807) （82127807）
上海市分子影像学重点实验室建设项目(18DZ2260400)Supported by National Natural Science Foundation of China(82127807) （18DZ2260400）
