分子影像学杂志2024，Vol.47Issue(12)：1308-1313,6.DOI:10.12122/j.issn.1674-4500.2024.12.06
MRI联合鳞状上皮细胞癌抗原对宫颈癌淋巴结转移的术前预测
Preoperative prediction of MRI combined with squamous cell carcinoma antigen for cervical cancer lymph node metastasis
摘要
Abstract
Objective To analyze the value of MRI and squamous cell carcinoma antigen(SCC-Ag)in combination to predict lymph node metastasis of cervical cancer.Methods The clinical and MRI data of 151 patients with cervical cancer who attended the First Affiliated Hospital of Bengbu Medical University from October 2022 to July 2024 were collected and analyzed.All the patients were categorized into non-lymph node metastasis group(n=83)and lymph node metastasis group(n=68)based on postoperative pathological results.Age,maximum tumor diameter,minor diameter of lymph noder,paracervical infiltration,vaginal involvement and the level of SCC-Ag between the two groups of patients were compared,and the prognostic value of lymph node metastasis of cervical cancer was assessed by multiple indicators.Results The results of univariate analysis showed that the factors affecting lymph node metastasis were the maximum diameter of the tumor,minor diameter of lymph noder,vaginal involvement,and the level of SCC-Ag(P<0.05).Binary Logistic regression analysis showed that maximum tumor diameter,minor diameter of lymph node,SCC-Ag,paracentral infiltration,and vaginal involvement were all independent influencing factors that could predict the risk of lymph node metastasis(P<0.05).The area under ROC curve of maximum tumor diameter,minor diameter of lymph node,SCC-Ag,maximum tumor diameter and minor diameter of lymph node,combined with SCC-Ag,multiple indicators combined(maximum tumor diameter,minor diameter of lymph node,SCC-Ag,paracentral invasion,and vaginal involvement)were 0.658,0.972,0.682,0.979,0.988,respectively,sensitivity was 62.4%,65.7%,59.3%,78.7%,89.8%,and specificity was 76.7%,88.2%,72.1%,84.5%,86.9%,respectively.The cut-off values of minor diameter of lymph node,and SCC-Ag were 8.5 mm and 5.85 ng/mL,respectively,and the maximum entry index were 0.652 and 0.543,respectively.Conclusion MRI and SCC-Ag used alone for lymph node metastasis prediction have low sensitivity,while sensitivity and specificity improve significantly when multiple metrics are used in combination,and the predictive value of lymph node metastasis is higher when MRI and SCC-Ag are used together.关键词
磁共振成像/鳞状细胞癌抗原/宫颈癌/淋巴结转移Key words
magnetic resonance imaging/squamous cell carcinoma antigen/cervical cancer/lymph node metastasis引用本文复制引用
单丹丹,邹文涛,晋茂生,马宜传..MRI联合鳞状上皮细胞癌抗原对宫颈癌淋巴结转移的术前预测[J].分子影像学杂志,2024,47(12):1308-1313,6.基金项目
安徽省高校科学研究项目(KJ2019A0363) （KJ2019A0363）
