辐射防护2024，Vol.44Issue(6)：711-717,7.
纳米氧化铋软膏对放射性皮肤损伤的防护作用
Protection effects of a nano-bismuth oxide cream against skin injury induced by radiation
摘要
Abstract
To protect the skin of interventional therapy operators from radioactive damage,a bismuth oxide nano ointment has been developed.Various proportion of bismuth oxide cream were prepared,through rats model to assess the protetion effect against acute radiation skin injury induced by 40 Gy X-ray exposure.Then the mice exposed to 4 Gy γ-ray TBI induced the hemopoietic system stress,and the prevention effects of the various proportion bismuth oxide creams were analyzed by WBC counts,PLT counts and bone marrow nucleated cells counts.And the radionuclide 125 I was administrated i.v.to the mice and SPECT scan was performed.The shield efficiency of internal exposure was accessed between the bismuth oxide cream group and vehicle.The prevention of the bismuth oxide cream was observed by application on the skin of rats prior to the 40 Gy X-ray exposure.Various proportion bismuth oxide cream presented significant prevention effects on the hemopoietic system stress induced by 4 Gy gamma-ray TBI.The bismuth oxide cream applied on the skin of mouse effectively blocked the gamma photon generated by 125 I.关键词
纳米氧化铋/辐射防护/放射性皮肤损伤/软膏剂Key words
nano-bismuth oxide/radiation protection/radiodermatitis/cream分类
医药卫生引用本文复制引用
周晓靓,杨雨薇,刘金剑,唐海康,徐文清..纳米氧化铋软膏对放射性皮肤损伤的防护作用[J].辐射防护,2024,44(6):711-717,7.基金项目
中国医学科学院医学与健康科技创新工程(2021-I2M-1-042) （2021-I2M-1-042）
中央高校基本科研业务费(3332022066,3332022067) （3332022066,3332022067）
国家自然科学基金(82203970). （82203970）
