基础医学与临床2025，Vol.45Issue(1)：76-80,5.DOI:10.16352/j.issn.1001-6325.2025.01.0076
血清MC-CP、CCL26、DcR3水平在COPD并发OSAS诊断中的临床价值
Clinical value of serum levels of MC-CP,CCL26 and DcR3 in the diagnosis of COPD complicated with OSAS
摘要
Abstract
Objective To investigate the clinical value of serum mast cell carboxypeptidase(MC-CP),C-C motif chemokine 26(CCL26),and decoy receptor 3(DcR3)in the diagnosis of obstructive sleep apnea syndrome(OSAS)in chronic obstructive pulmonary disease(COPD).Methods Ninety COPD patients who visited the First Affiliated Hospital of Hebei North University from January 2021 to January 2023 were collected.Among them,48 patients with simple COPD were included in the COPD group,and 42 patients with COPD combined with OSAS were included in the COPD-OSAS group.During the same period,48 healthy volunteers who underwent physical examination in that Hospital of Hebei North collected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect serum level of MC-CP,CCL26,and DcR3.Receiver operating characteristic(ROC)curve was applied to analyze the clinical value of serum level of MC-CP,CCL26,and DcR3 in the diag-nosis of COPD complicated with OSAS.Multivariate Logistic regression was applied to analyze the influencing fac-tors of COPD complicated with OSAS.Results Compared with the control group,the smoking index,C-reactive protein(CRP)and white blood cell count(WBC)in the COPD and COPD-OSAS groups increased obviously in sequence,the ratio of forced expiratory volume in first second to forced vital capacity(FEV1/FVC)decreased obviously in sequence(P<0.05);Compared with the control group,the level of MC-CP,CCL26,and DcR3 in patients with COPD and COPD-OSAS increased significantly in sequence(P<0.05);The combination of serum MC-CP,CCL26 and DcR3 had a higher area under the curve(AUC)for the diagnosis of COPD complicated with OSAS compared to the individual diagnosis(Z=4.066,P<0.001;Z=2.391,P<0.05;Z=2.353,P<0.05).Multivariate Logistic regression analysis showed that smoking index,serum level of MC-CP,CCL26 and DcR3 were influencing factors for COPD complicated with OSAS(P<0.05).Conclusions The simultane-ously increased expression of MC-CP,CCL26 and DcR3 in the serum of COPD may support clinical diagnostic of COPD patients with OSAS.关键词
肥大细胞羧肽酶/趋化因子26/诱饵受体3/慢性阻塞性肺疾病/阻塞性睡眠呼吸暂停综合征Key words
mast cell carboxypeptidase/C-C motif chemokine 26/decoy receptor 3/chronic obstructive pulmonary disease/obstructive sleep apnea syndrome分类
医药卫生引用本文复制引用
陈丽萍,史永兴,陈艳红,冯平,张长洪,林卫佳,项保利..血清MC-CP、CCL26、DcR3水平在COPD并发OSAS诊断中的临床价值[J].基础医学与临床,2025,45(1):76-80,5.基金项目
张家口市科学技术局2021年市级科技计划自筹经费项目(2121162D) （2121162D）
