解放军医学院学报2024，Vol.45Issue(10)：1072-1074,1102,4.DOI:10.12435/j.issn.2095-5227.2024.128
肺腺癌伴EGFR和KIF5B-MET共突变1例并文献复习
Lung adenocarcinoma with EGFR and KIF5B-MET co-mutations:A case report
徐凯文 1董周寰 1朱凤伟 1陈雷 2高杰1
作者信息
- 1. 解放军总医院第一医学中心病理科,北京 100853
- 2. 解放军总医院第一医学中心胸外科,北京 100853
- 折叠
摘要
Abstract
With the development of genetic testing technology,it has become a mainstream to detect molecular alterations in lung cancer patients to guide clinical targeted therapy.This article reports a 51 year-old male patient diagnosed as lung adenocarcinoma in the molecular pathology diagnostic laboratory of Department of Pathology of the First Medical Center of Chinese PLA General Hospital,with clinical TNM stage T1bN0M0,and double mutation of rare gene fusion of EGFR(L858R)and KIF5B-MET by second-generation sequencing.The patient underwent video-assisted thoracoscopic surgery(VATS),which involved resection of the upper lobe of the right lung and clearance of the mediastinal lymph nodes.After surgery,no targeted therapy or radiotherapy was performed,and the prognosis was good since the follow-up.By analyzing the clinical data,diagnosis and treatment process and disease regression of the patient,the new mutation forms and related therapeutic targets in non-small cell lung cancer(NSCLC)patients are investigated,suggesting that early radical lung cancer treatment is effective,and second-generation sequencing is important for identifying rare mutations and therapeutic targets.关键词
肺癌/EGFR突变/KIF5B-MET融合/二代测序/分子病理Key words
lung cancer/EGFR mutation/KIF5B-MET fusion/next-generation sequencing/molecular pathology分类
医药卫生引用本文复制引用
徐凯文,董周寰,朱凤伟,陈雷,高杰..肺腺癌伴EGFR和KIF5B-MET共突变1例并文献复习[J].解放军医学院学报,2024,45(10):1072-1074,1102,4.
