基础医学与临床2025，Vol.45Issue(1)：86-90,5.DOI:10.16352/j.issn.1001-6325.2025.01.0086
血清PKM2、Gal-3、CitH3水平升高可预测机械通气并发肺部感染
Elevated levels of serum PKM2,Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation
摘要
Abstract
Objective To investigate the relationship between serum level of pyruvate kinase M2(PKM2),galec-tin-3(Gal-3)and citrolinated histone H3(CitH3)and pulmonary infection in patients with mechanical ventilation(MV).Methods A total of 120 patients with MV admitted to Jinhua Central Hospital from October 2022 to March 2024 were included in the study.They were divided into pulmonary infection group(n=50)and non-pulmonary in-fection group(n=70).Serum level of PKM2,Gal-3 and CitH3 was detected by ELISA.The patients were divided into good prognosis group(n=79)and bad prognosis group(n=41).Multivariate Logistic regression analysis was performed to analyze the factors affecting the adverse prognosis of MV patients.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum PKM2,Gal-3 and CitH3 for poor prognosis in pa-tients undergoing MV.Results Compared with non-pulmonary infection group,serum level of PKM2,Gal-3 and CitH3 in pulmonary infection group was increased(P<0.05).The level of serum PKM2,Gal-3 and CitH3 in the poor prognosis group was increased(P<0.05).The Clinical Pulmonary Infection score(CPIS)of the poor progno-sis group was higher than that of the good prognosis group(P<0.05).PKM2,Gal-3 and CitH3 were all risk factors for poor prognosis in MV patients(P<0.05).The area under the curve(AUC)of PKM2,Gal-3,CitH3 and com-bined prediction of poor prognosis were 0.712,0.839,0.779 and 0.925,respectively.AUC of combined diagnosis of PKM2,GAL-3,CITH3 and combined diagnosis was better than that of single detection(Z=4.261,2.521,3.676,P<0.001,0.05,0.001).Conclusions The serum level of PKM2,Gal-3,and CitH3 in MV patients with concurrent pulmonary infections is found to be higher than those in those without pulmonary infections,so these three factors have potential predictive value for poor prognosis of MV patients.关键词
机械通气/肺部感染/丙酮酸激酶M2(PKM2)/乳糖凝集素-3(Gal-3)/瓜氨酸化组蛋白H3(CitH3)/预后Key words
mechanical ventilation/pulmonary infection/pyruvate kinase M2(PKM2)/galectin-3(Gal-3)/citrullinated histone H3(CitH3)/prognosis分类
医药卫生引用本文复制引用
黄航栋,厉丹瑜,朱晓锋..血清PKM2、Gal-3、CitH3水平升高可预测机械通气并发肺部感染[J].基础医学与临床,2025,45(1):86-90,5.基金项目
2021年浙江省医师协会临床研究基金(YS2021-1-016) （YS2021-1-016）
