解放军医学院学报2024，Vol.45Issue(10)：1085-1090,6.DOI:10.12435/j.issn.2095-5227.2024.132
脊髓损伤中线粒体功能障碍机制及其治疗策略研究进展
Research advances in role of mitochondria in spinal cord injury and regeneration
摘要
Abstract
Spinal cord injury(SCI)is a condition that severely impacts patients'quality of life.Treatment strategies mainly focus on alleviating initial injury,reducing secondary damage,promoting nerve regeneration,and improving functional recovery.Mitochondrial dysfunction plays a critical role in the pathophysiology following SCI.Recent studies have shown that mitochondrial structural damage and dysfunction are significant contributors to secondary injury after SCI,directly affecting the survival and regenerative capacity of nerve cells.Therefore,protecting mitochondrial structure and enhancing mitochondrial activity have become key areas in spinal cord regeneration research and may potentially offer new therapeutic strategies for SCI.This article reviews the mechanisms by which mitochondria influence SCI and their therapeutic potential in promoting spinal cord regeneration,including uncoupling agents,inhibition of mitochondrial permeability transition pore opening,regulation of mitochondrial fission and fusion,modulation of mitochondrial biogenesis,and mitochondrial transplantation.Future research should further explore the interactions between mitochondria and other cellular systems,aiming to translate mitochondrial therapeutic strategies into clinical applications for SCI,thereby providing more effective treatment options for patients.关键词
脊髓损伤/线粒体功能障碍/脊髓再生/线粒体自噬/治疗方案Key words
spinal cord injury/mitochondrial dysfunction/spinal cord regeneration/mitochondrial autophagy/treatment options分类
医药卫生引用本文复制引用
毛志昊,任博文,郭子轩,刘建恒..脊髓损伤中线粒体功能障碍机制及其治疗策略研究进展[J].解放军医学院学报,2024,45(10):1085-1090,6.基金项目
国家自然科学基金项目(82372401) （82372401）
北京市自然科学基金资助项目(L202033) （L202033）
