基础医学与临床2025，Vol.45Issue(1)：102-106,5.DOI:10.16352/j.issn.1001-6325.2025.01.0102
脑衰反应调节蛋白在视神经损伤中的作用
Role of collapsin response mediator proteins in optic nerve injury
摘要
Abstract
Collapsin response mediator proteins(CRMPs),also known as dihydropyrimidine-like proteins,contain five isoforms(CRMP1,CRMP2,CRMP3,CRMP4,CRMP5).In central nervous system,CRMPs are mainly in-volved in a variety of physiological processes such as neuronal differentiation and migration,synaptic plasticity,neurite growth and development and guiding extension.Recent studies have found that inhibiting or reducing the phosphorylation of CRMPs can affect the survival and axonal regeneration of retinal ganglion cells(RGCs)after op-tic nerve injury,which may provide new ideas for the treatment of optic nerve injury in the future.关键词
脑衰反应调节蛋白/视神经损伤/视网膜神经节细胞/轴突再生Key words
collapsin response mediator proteins/optic nerve injury/retinal ganglion cell/axonal regeneration分类
医药卫生引用本文复制引用
朱裕椿,席鑫源,杨珍,冯东福..脑衰反应调节蛋白在视神经损伤中的作用[J].基础医学与临床,2025,45(1):102-106,5.基金项目
国家自然科学基金(82271388) （82271388）
上海市自然科学基金(22ZR1452700) （22ZR1452700）
