基础医学与临床2025，Vol.45Issue(1)：107-111,5.DOI:10.16352/j.issn.1001-6325.2025.01
Keap1翻译后修饰调控氧化应激相关疾病
Post-translational modification of Keap1 regulates oxidative stress-related diseases
摘要
Abstract
The activation of Keap1-Nrf2 signaling pathway is an important mechanism for cells to resist oxidative stress.Under oxidative stress,Keap1 is affected by post-translational modification(PTM)such as glutathione,alky-lation and S-sulfhydrylation,which weakens its binding to Nrf2,leading to Nrf2 accumulation,nuclear translocation and the expression and transcription of downstream detoxification and antioxidant defense proteins.The PTM of Keap1 is involved in the regulation of a variety of oxidative stress-related diseases such as cancer,Parkin-son's disease and atherosclerosis.For example,alkylation inhibits abdominal aortic aneurysm formation,methylation promotes innate resistance of breast cancer,and S-sulfhydrylation improves atherosclerosis,which pro-vides a theoretical basis for finding new drug targets and biomarkers.关键词
Keap1/氧化应激/翻译后修饰/作用机制Key words
Keap1/oxidative stress/post-translational modifications/mechanism of action分类
医药卫生引用本文复制引用
瞿瑛,毛彩云,钟晴,张蓉,宋运佳..Keap1翻译后修饰调控氧化应激相关疾病[J].基础医学与临床,2025,45(1):107-111,5.基金项目
国家自然科学基金(82204792) （82204792）
中国博士后科学基金(2002M711089) （2002M711089）
