解放军医学院学报2024，Vol.45Issue(10)：1096-1102,7.DOI:10.12435/j.issn.2095-5227.2024.106
纳米光动力治疗皮肤黑色素瘤的研究进展
Research advances in nano-photodynamic therapy for treatment of cutaneous melanoma
梁纯 1陈犹白 1路亚静 2殷祥烨 3何添 3陈东升 3张广良 3杨怡 4李文亮 5邱海霞2
作者信息
- 1. 解放军总医院第一医学中心整形修复科,北京 100853||内蒙古医科大学,内蒙古呼和浩特 010110
- 2. 解放军总医院第一医学中心激光科,北京 100853
- 3. 解放军总医院第一医学中心整形修复科,北京 100853
- 4. 解放军总医院第一医学中心皮肤科,北京 100853
- 5. 长春理工大学化学与环境工程学院,吉林长春 130022
- 折叠
摘要
Abstract
Cutaneous melanoma is a highly malignant skin cancer with low survival rate.Traditional treatment such as surgery is associated with certain recurrence rate.Photodynamic therapy produces cytotoxic reactive oxygen species by photoactivating photosensitizers to kill tumor cells,which is a promising treatment for cutaneous melanoma.However,limitations of conventional photosensitizer,including low permeability,unspecific targeting,and inadequate therapeutic effect,significantly restrict the clinical application of photodynamic therapy in treating cutaneous melanoma.It is crucial to improve the effectiveness and safety of photodynamic therapy through modification of the photosensitizer.This review focuses on the research advances in nanophotodynamic therapy for cutaneous melanoma,including the types of nanoparticles and nano-photosensitizers,the release mechanism of photosensitizer,and the benefits and limitations of nanophotodynamic therapy.Nanoparticles can enhance the targeting capacity of photosensitizer,increase the intratumoral accumulation of photosensitizer,and improve the hypoxic microenvironment.In addition,multifunctional nanoparticles can synergize photodynamic therapy with fluorescence imaging,immunotherapy/gene therapy,chemotherapy,and photothermal therapy to achieve better treatment effectiveness and safety.Although nanophotodynamic therapy has high manufacturing cost,low reproducibility,and unconfirmed long-term in-vivo safety,it overcomes the limitations of traditional photodynamic therapy and offers a novel method for treatment of cutaneous melanoma.关键词
黑色素瘤/光动力疗法/光敏剂/纳米技术/纳米颗粒Key words
melanoma/photodynamic therapy/photosensitizer/nanotechnology/nanoparticles分类
医药卫生引用本文复制引用
梁纯,陈犹白,路亚静,殷祥烨,何添,陈东升,张广良,杨怡,李文亮,邱海霞..纳米光动力治疗皮肤黑色素瘤的研究进展[J].解放军医学院学报,2024,45(10):1096-1102,7.
