基础医学与临床2025，Vol.45Issue(1)：130-134,5.DOI:10.16352/j.issn.1001-6325.2025.01.0130
幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制
Mechanism of spasmolytic polypeptide-expressing metaplasia in gastric mucosa induced by Helicobacter pylori infection
摘要
Abstract
Helicobacter pylori(H.pylori)infection triggers gastric mucosal inflammatory responses and spasmolytic polypeptide-expressing metaplasia(SPEM).These pathological conditions can escalate the severity of chronic gas-tritis,gastric ulcers and even cause gastric cancer.SPEM is frequently viewed as an early sign of gastric mucosal injury and the onset of carcinogenesis.A comprehensive analysis of the genesis and molecular regulation of SPEM cells in the context of H.pylori infection further has enlightened the pathogenesis of gastric mucosal diseases and provide new ideas and targets for diagnosing and treatment of H.pylori-related gastric mucosal diseases.This paper reviews a variety of molecular biomarkers associated with SPEM,encompassing TFF2,CD44v9,and AQP5,and delineates their pivotal regulatory functions in H.pylori infection and SPEM.This paper also reviews the origination of SPEM cells and pertinent molecular regulatory mechanisms.关键词
幽门螺杆菌/胃黏膜解痉多肽表达化生Key words
Helicobacter pylori/spasmolytic polypeptide-expressing metaplasia分类
基础医学引用本文复制引用
王海诺,李玙璠,王雨莹,沈倩影,朱进霞,郑丽飞..幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制[J].基础医学与临床,2025,45(1):130-134,5.基金项目
首都医科大学2021年度第二课堂项目(D2KT2021037) （D2KT2021037）
科技部重点专项(2016YFC1302203) （2016YFC1302203）
