昆明医科大学学报2024，Vol.45Issue(12)：147-152,6.DOI:10.12259/j.issn.2095-610X.S20241221
血清抗-HBC、CHE、载脂蛋白AI的水平与病毒性肝炎发展的相关性
Correlation between Serum Levels of Anti-HBC,CHE,and Apolipoprotein AI and the Development of Viral Hepatitis
摘要
Abstract
Objective To investigate the correlation between serum hepatitis B core anbody(anti-HBC),cholinesterase(CHE)and apolipoprotein AI(ApoAI)and the development of viral hepatitis.Methods 388 patients with viral hepatitis admitted to Nanjing Pukou District Hospital of Traditional Chinese Medicine from January 2021 to January 2024 were selected as the observation group,another 68 cases of health check-ups in medical check-up centre of Nanjing Pukou District Hospital of Traditional Chinese Medicine during the same period were selected as the control group.The serum levels of anti-HBC,CHE,and apolipoprotein AI between the observation group and the control group were compared.To compare the serum anti-HBC,CHE,ApoAI levels in patients with different disease severity of chronic hepatitis in the observation group.To compare the number of positive cases of serum anti-HBC,CHE,ApoAI in patients with different disease types in the observation group.To compare the serum anti-HBC,CHE,ApoAI levels in patients with different grades of cirrhosis in the observation group.Results Serum anti-HBC levels(4.52±0.63)log10PEIU/mL were higher in the observation group than in the control group(1.12±0.26)log10PEIU/mL,and the differences were statistically significant(t=-43.822,P＜0.001),while CHE(4.09±0.91)kU/L,ApoAI(102.54±5.95)mg/dL were lower than the control group(10.65±1.73)kU/L,(120.17±6.06)mg/dL,and the differences were statistically significant(t=46.580,22.477,P＜0.001);differences in serum anti-HBC,CHE,and ApoAI levels among patients with different severity of chronic hepatitis in the observation group were statistically significant(P＜0.05),and the serum levels of anti-HBC levels showed mild chronic hepatitis＜moderate chronic hepatitis＜severe chronic hepatitis,while the levels of CHE and ApoAI showed mild chronic hepatitis＞moderate chronic hepatitis＞severe chronic hepatitis the difference was statistically significant(P＜0.05);the number of positive cases of serum anti-HBC,CHE,ApoAI in acute jaundiced hepatitis,severe chronic hepatitis,cirrhosis and hepatocellular carcinoma were significantly higher than those of chronic hepatitis in mild and moderate forms and the difference was statistically significant(P＜0.05).The differences in serum anti-HBC,CHE,and ApoAI levels in patients with different grades of cirrhosis in the observation group were statistically significant(P＜0.05)and serum levels of anti-HBC levels increased continuously with the progression of the disease,whereas CHE and ApoAI decreased continuously with the difference being statistically significant(P＜0.05).Conclusion The levels of serum anti-HBC in patients with viral hepatitis are significantly increased,while the levels of CHE and apolipoprotein AI are significantly decreased,and the levels of serum anti-HBC,CHE and apolipoprotein AI are related to the development of the disease,which contributes to the development of the disease.关键词
病毒性肝炎/抗-HBC/胆碱酯酶/载脂蛋白Key words
Viral hepatitis/Hepatitis B core anbody/Cholinesterase/Apolipoprotein分类
医药卫生引用本文复制引用
徐苏,刘宇晴,郑兴旺..血清抗-HBC、CHE、载脂蛋白AI的水平与病毒性肝炎发展的相关性[J].昆明医科大学学报,2024,45(12):147-152,6.基金项目
浦口区科技计划项目(S2022-27) （S2022-27）
