昆明医科大学学报2024，Vol.45Issue(12)：153-159,7.DOI:10.12259/j.issn.2095-610X.S20241222
脂代谢和肝功能指标对糖尿病前期的预测作用
Analysis of the Predictive Effects of Lipid Metabolism and Liver Function Indicators on Prediabetes
摘要
Abstract
Objective To study the relationship between lipid metabolism and liver function indexes in prediabetic population,and explore the predictive value of these indexes for prediabetes.Methods 546 patients with prediabetes who underwent physical examination in the First Affiliated Hospital of Xi'an Jiaotong University from April 2020 to August 2021 were selected as case group(PreDM group)and 546 patients with normal glucose tolerance as control group(NGT group).There was no significant difference in baseline data between the two groups after tendency matching score.The levels of lipid metabolism and liver function indicators were compared between the two groups;the correlation between lipid metabolism and liver function indicators in the PreDM group was analyzed;the influencing factors of prediabetes were screened by using binary logistic regression analysis;the predictive effect of lipid metabolism and liver function indicators on prediabetes was judged by using the ROC curve.Results Glutamic pyruvic transaminase(ALT),glutamic pyruvic transaminase/glutamic oxaloacetic transaminase ratio(ALT/AST),cholinesterase(CHE),gamma glutamyltransferase(GGT),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol/high density lipoprotein cholesterol ratio(TC/HDL-C)and triglyceride/high density lipoprotein cholesterol ratio(TG/HDL-C)in PreDM group were higher than those in NGT group(all P＜0.05).Spearman correlation analysis showed that TG/HDL-C in PreDM group had the positive correlation with ALT,ALT/AST,CHE and GGT(r=0.256,0.256,0.293,0.122,all P＜0.05).Multivariate stepwise logistic regression analysis showed that ALT/AST,GGT,TC/HDL-C and TG/HDL-C had the greatest effect on prediabetes(OR=2.124,1.027,1.196,1.260),and the combination of the four had the highest differential diagnostic value(AUC＞0.70).Conclusion There are more abnormal indexes of blood lipid and liver zymogram in prediabetic population,and the combination of ALT/AST,GGT,TC/HDL-C and TG/HDL-C is more effective in predicting prediabetes.关键词
糖尿病前期/体检/脂代谢/相关性/肝功能Key words
Prediabetic/Physical examination/Lipid metabolism/Correlation/Liver function分类
医药卫生引用本文复制引用
马燕粉,刘洒洒,胡健,蔡德佩,乔永峰,王晓琴..脂代谢和肝功能指标对糖尿病前期的预测作用[J].昆明医科大学学报,2024,45(12):153-159,7.基金项目
陕西省自然科学基金青年项目(2022JQ-866) （2022JQ-866）
